Human Gene ZNF347 (ENST00000452676.6) Description and Page Index
  Description: Homo sapiens zinc finger protein 347 (ZNF347), transcript variant 1, mRNA. (from RefSeq NM_001172674)
Gencode Transcript: ENST00000452676.6
Gencode Gene: ENSG00000197937.12
Transcript (Including UTRs)
   Position: hg38 chr19:53,138,705-53,159,060 Size: 20,356 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr19:53,140,308-53,153,747 Size: 13,440 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:53,138,705-53,159,060)mRNA (may differ from genome)Protein (840 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZN347_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 347; AltName: Full=Zinc finger protein 1111;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 20 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.65 RPKM in Brain - Cerebellum
Total median expression: 81.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.10427-0.328 Picture PostScript Text
3' UTR -435.001603-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2EMA
- NMR MuPIT

2EMP
- NMR MuPIT

2EN4
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2ENE - NMR MuPIT 2ENF - NMR MuPIT 2EOE - NMR MuPIT
2EOW - NMR MuPIT 2EQ0 - NMR MuPIT 2EQ1 - NMR MuPIT
2EQ2 - NMR MuPIT 2EQ3 - NMR MuPIT 2YTI - NMR MuPIT
2YTK - NMR MuPIT 2YTN - NMR MuPIT 2YTR - NMR MuPIT
2YU8 - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q96SE7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AL713691 - Homo sapiens mRNA; cDNA DKFZp547F1510 (from clone DKFZp547F1510).
AY029765 - Homo sapiens zinc finger 1111 mRNA, complete cds.
JD114044 - Sequence 95068 from Patent EP1572962.
JD225693 - Sequence 206717 from Patent EP1572962.
JD304766 - Sequence 285790 from Patent EP1572962.
JD496902 - Sequence 477926 from Patent EP1572962.
BC002938 - Homo sapiens cDNA clone IMAGE:3956647, containing frame-shift errors.
BC015611 - Homo sapiens cDNA clone IMAGE:4810955, containing frame-shift errors.
AK095593 - Homo sapiens cDNA FLJ38274 fis, clone FCBBF3003787, highly similar to Homo sapiens zinc finger 1111 mRNA.
AK096623 - Homo sapiens cDNA FLJ39304 fis, clone OCBBF2013049, highly similar to Zinc finger protein 347.
JD269342 - Sequence 250366 from Patent EP1572962.
JD143954 - Sequence 124978 from Patent EP1572962.
JD257618 - Sequence 238642 from Patent EP1572962.
JD352000 - Sequence 333024 from Patent EP1572962.
JD448433 - Sequence 429457 from Patent EP1572962.
JD332409 - Sequence 313433 from Patent EP1572962.
JD308932 - Sequence 289956 from Patent EP1572962.
JD096451 - Sequence 77475 from Patent EP1572962.
JD177499 - Sequence 158523 from Patent EP1572962.
JD238443 - Sequence 219467 from Patent EP1572962.
JD135895 - Sequence 116919 from Patent EP1572962.
JD537999 - Sequence 519023 from Patent EP1572962.
JD230803 - Sequence 211827 from Patent EP1572962.
JD135507 - Sequence 116531 from Patent EP1572962.
JD114222 - Sequence 95246 from Patent EP1572962.
JD482699 - Sequence 463723 from Patent EP1572962.
JD438848 - Sequence 419872 from Patent EP1572962.
JD264160 - Sequence 245184 from Patent EP1572962.
JD477824 - Sequence 458848 from Patent EP1572962.
JD111741 - Sequence 92765 from Patent EP1572962.
JD420152 - Sequence 401176 from Patent EP1572962.
AK289994 - Homo sapiens cDNA FLJ78363 complete cds.
JD294294 - Sequence 275318 from Patent EP1572962.
JD327724 - Sequence 308748 from Patent EP1572962.
JD363299 - Sequence 344323 from Patent EP1572962.
JD305270 - Sequence 286294 from Patent EP1572962.
JD434156 - Sequence 415180 from Patent EP1572962.
JD263347 - Sequence 244371 from Patent EP1572962.
JD093576 - Sequence 74600 from Patent EP1572962.
BC136255 - Homo sapiens zinc finger protein 347, mRNA (cDNA clone MGC:167865 IMAGE:9020242), complete cds.
BC143412 - Homo sapiens cDNA clone IMAGE:9051920.
JD314888 - Sequence 295912 from Patent EP1572962.
JD431417 - Sequence 412441 from Patent EP1572962.
D70832 - Homo sapiens mRNA for Zinc-finger protein, partial cds.
AK314603 - Homo sapiens cDNA, FLJ95441, highly similar to Homo sapiens zinc finger protein 347 (ZNF347), mRNA.
AB464392 - Synthetic construct DNA, clone: pF1KB9764, Homo sapiens ZNF347 gene for zinc finger protein 347, without stop codon, in Flexi system.
LF344968 - JP 2014500723-A/152471: Polycomb-Associated Non-Coding RNAs.
MA580545 - JP 2018138019-A/152471: Polycomb-Associated Non-Coding RNAs.
JD314871 - Sequence 295895 from Patent EP1572962.
LF344967 - JP 2014500723-A/152470: Polycomb-Associated Non-Coding RNAs.
MA580544 - JP 2018138019-A/152470: Polycomb-Associated Non-Coding RNAs.
LF344967 - JP 2014500723-A/152470: Polycomb-Associated Non-Coding RNAs.
MA580544 - JP 2018138019-A/152470: Polycomb-Associated Non-Coding RNAs.
LF344966 - JP 2014500723-A/152469: Polycomb-Associated Non-Coding RNAs.
MA580543 - JP 2018138019-A/152469: Polycomb-Associated Non-Coding RNAs.
JD084021 - Sequence 65045 from Patent EP1572962.
JD084022 - Sequence 65046 from Patent EP1572962.
LF344965 - JP 2014500723-A/152468: Polycomb-Associated Non-Coding RNAs.
MA580542 - JP 2018138019-A/152468: Polycomb-Associated Non-Coding RNAs.
LF357294 - JP 2014500723-A/164797: Polycomb-Associated Non-Coding RNAs.
MA592871 - JP 2018138019-A/164797: Polycomb-Associated Non-Coding RNAs.
LF357293 - JP 2014500723-A/164796: Polycomb-Associated Non-Coding RNAs.
MA592870 - JP 2018138019-A/164796: Polycomb-Associated Non-Coding RNAs.
LF340518 - JP 2014500723-A/148021: Polycomb-Associated Non-Coding RNAs.
MA576095 - JP 2018138019-A/148021: Polycomb-Associated Non-Coding RNAs.
LF357292 - JP 2014500723-A/164795: Polycomb-Associated Non-Coding RNAs.
MA592869 - JP 2018138019-A/164795: Polycomb-Associated Non-Coding RNAs.
LF344964 - JP 2014500723-A/152467: Polycomb-Associated Non-Coding RNAs.
MA580541 - JP 2018138019-A/152467: Polycomb-Associated Non-Coding RNAs.
LF340517 - JP 2014500723-A/148020: Polycomb-Associated Non-Coding RNAs.
MA576094 - JP 2018138019-A/148020: Polycomb-Associated Non-Coding RNAs.
LF340516 - JP 2014500723-A/148019: Polycomb-Associated Non-Coding RNAs.
MA576093 - JP 2018138019-A/148019: Polycomb-Associated Non-Coding RNAs.
LF340515 - JP 2014500723-A/148018: Polycomb-Associated Non-Coding RNAs.
MA576092 - JP 2018138019-A/148018: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96SE7 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B9EG59, NM_001172674, Q8TCN1, Q96SE7, uc002qbc.1, uc002qbc.2, uc002qbc.3, ZN347_HUMAN, ZNF1111
UCSC ID: uc002qbc.3
RefSeq Accession: NM_001172674
Protein: Q96SE7 (aka ZN347_HUMAN or Z347_HUMAN)
CCDS: CCDS33097.1, CCDS54314.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.