ID:CCNL1_HUMAN DESCRIPTION: RecName: Full=Cyclin-L1; Short=Cyclin-L; FUNCTION: Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21. SUBUNIT: Interacts with POLR2A via its hyperphosphorylated C- terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12, CDK13 and SFRS2. SUBCELLULAR LOCATION: Nucleus speckle (By similarity). Note=More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing (By similarity). TISSUE SPECIFICITY: Ubiquitous with higher level in thymus. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). DOMAIN: Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions. MISCELLANEOUS: CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC. SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily. SEQUENCE CAUTION: Sequence=AAF64257.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAQ89026.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UK58
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006396 RNA processing GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain