Human Gene KLHL21 (ENST00000463043.1) from GENCODE V44
  Description: Homo sapiens kelch like family member 21 (KLHL21), transcript variant 2, mRNA. (from RefSeq NM_001324309)
Gencode Transcript: ENST00000463043.1
Gencode Gene: ENSG00000162413.17
Transcript (Including UTRs)
   Position: hg38 chr1:6,594,081-6,614,607 Size: 20,527 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr1:6,594,108-6,599,372 Size: 5,265 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:6,594,081-6,614,607)mRNA (may differ from genome)Protein (133 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIOMIMPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.41 RPKM in Muscle - Skeletal
Total median expression: 791.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -122.20238-0.513 Picture PostScript Text
3' UTR -1.8027-0.067 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK075305 - Homo sapiens cDNA FLJ90824 fis, clone Y79AA1001430, highly similar to Homo sapiens kelch-like 21 (Drosophila) (KLHL21), mRNA.
AB007938 - Homo sapiens mRNA for KIAA0469 protein, partial cds.
BC064980 - Homo sapiens kelch-like 21 (Drosophila), mRNA (cDNA clone IMAGE:6577755).
BC091648 - Homo sapiens kelch-like 21 (Drosophila), mRNA (cDNA clone MGC:99635 IMAGE:6373903), complete cds.
BC034039 - Homo sapiens kelch-like 21 (Drosophila), mRNA (cDNA clone MGC:26467 IMAGE:4811534), complete cds.
AK090472 - Homo sapiens mRNA for FLJ00393 protein.
BC111766 - Homo sapiens kelch-like 21 (Drosophila), mRNA (cDNA clone IMAGE:40026322), complete cds.
AK307564 - Homo sapiens cDNA, FLJ97512.

-  Other Names for This Gene
  Alternate Gene Symbols: K7EMF2, NM_001324309, uc057bvz.1
UCSC ID: ENST00000463043.1
RefSeq Accession: NM_001324309

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.