Human Gene RAD51B (ENST00000487270.5) Description and Page Index
Description: Homo sapiens RAD51 paralog B (RAD51B), transcript variant 3, mRNA. (from RefSeq NM_133509) RefSeq Summary (NM_133509): The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]. Gencode Transcript: ENST00000487270.5 Gencode Gene: ENSG00000182185.18 Transcript (Including UTRs) Position: hg38 chr14:67,819,808-68,595,996 Size: 776,189 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr14:67,823,544-68,594,603 Size: 771,060 Coding Exon Count: 10
ID:RA51B_HUMAN DESCRIPTION: RecName: Full=DNA repair protein RAD51 homolog 2; Short=R51H2; AltName: Full=RAD51 homolog B; Short=Rad51B; AltName: Full=RAD51-like protein 1; FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B- RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single- stranded gaps in duplex DNA and specifically to nicks in duplex DNA. SUBUNIT: Interacts with RAD51C. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51C and RAD51. Interacts with SWSAP1; involved in homologous recombination repair. INTERACTION: Q6NVH7:SWSAP1; NbExp=2; IntAct=EBI-2824089, EBI-5281637; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in a wide range of tissues. DISEASE: Note=A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23- 24) with HMGA1. DISEASE: Note=A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2. SIMILARITY: Belongs to the RecA family. RAD51 subfamily. SEQUENCE CAUTION: Sequence=CAD62357.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD66573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rad51l1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15315
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.