Human Gene HES2 (ENST00000489730.1) from GENCODE V44
  Description: hes family bHLH transcription factor 2 (from HGNC HES2)
Gencode Transcript: ENST00000489730.1
Gencode Gene: ENSG00000069812.11
Transcript (Including UTRs)
   Position: hg38 chr1:6,418,849-6,419,917 Size: 1,069 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr1:6,419,233-6,419,820 Size: 588 Coding Exon Count: 3 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:6,418,849-6,419,917)mRNA (may differ from genome)Protein (82 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.93 RPKM in Esophagus - Mucosa
Total median expression: 41.35 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -35.6097-0.367 Picture PostScript Text
3' UTR -180.20384-0.469 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  BC012091 - Homo sapiens hairy and enhancer of split 2 (Drosophila), mRNA (cDNA clone IMAGE:4634002), complete cds.
KJ902672 - Synthetic construct Homo sapiens clone ccsbBroadEn_12066 HES2 gene, encodes complete protein.
AK091122 - Homo sapiens cDNA FLJ33803 fis, clone CTONG2000561, highly similar to Transcription factor HES-2.
LF206747 - JP 2014500723-A/14250: Polycomb-Associated Non-Coding RNAs.
MA442324 - JP 2018138019-A/14250: Polycomb-Associated Non-Coding RNAs.
BC142687 - Homo sapiens hairy and enhancer of split 2 (Drosophila), mRNA (cDNA clone MGC:164997 IMAGE:40148619), complete cds.
BC132698 - Homo sapiens hairy and enhancer of split 2 (Drosophila), mRNA (cDNA clone MGC:164329 IMAGE:40146720), complete cds.
BC136963 - Homo sapiens hairy and enhancer of split 2 (Drosophila), mRNA (cDNA clone MGC:168578 IMAGE:9020955), complete cds.
LF211970 - JP 2014500723-A/19473: Polycomb-Associated Non-Coding RNAs.
MA447547 - JP 2018138019-A/19473: Polycomb-Associated Non-Coding RNAs.
JD391983 - Sequence 373007 from Patent EP1572962.
AB463714 - Synthetic construct DNA, clone: pF1KB7537, Homo sapiens HES2 gene for hairy and enhancer of split 2, without stop codon, in Flexi system.
LF357508 - JP 2014500723-A/165011: Polycomb-Associated Non-Coding RNAs.
MA593085 - JP 2018138019-A/165011: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK091122, K7EJQ0, uc057bug.1
UCSC ID: ENST00000489730.1
RefSeq Accession: NM_019089

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.