Human Gene ZNF415 (ENST00000500065.8) Description and Page Index
  Description: Homo sapiens zinc finger protein 415 (ZNF415), transcript variant 23, mRNA. (from RefSeq NM_001352148)
Gencode Transcript: ENST00000500065.8
Gencode Gene: ENSG00000170954.11
Transcript (Including UTRs)
   Position: hg38 chr19:53,107,883-53,132,888 Size: 25,006 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr19:53,108,377-53,122,418 Size: 14,042 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:53,107,883-53,132,888)mRNA (may differ from genome)Protein (555 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtPubMedReactomeStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 415;
FUNCTION: Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP- 1 and p53/TP53.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus.
TISSUE SPECIFICITY: Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1.
SIMILARITY: Contains 12 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.18 RPKM in Testis
Total median expression: 174.22 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.00334-0.311 Picture PostScript Text
3' UTR -90.90494-0.184 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q09FC8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton

-  Descriptions from all associated GenBank mRNAs
  DQ925695 - Homo sapiens zinc finger protein 415 isoform 1 (ZNF415) mRNA, complete cds.
DQ925698 - Homo sapiens zinc finger protein 415 isoform 4 (ZNF415) mRNA, complete cds.
DQ925696 - Homo sapiens zinc finger protein 415 isoform 2 (ZNF415) mRNA, complete cds.
AY283600 - Homo sapiens zinc finger protein 415 isoform 5 (ZNF415) mRNA, complete cds.
DQ925697 - Homo sapiens zinc finger protein 415 isoform 3 (ZNF415) mRNA, complete cds.
AK095504 - Homo sapiens cDNA FLJ38185 fis, clone FCBBF1000171, highly similar to Homo sapiens zinc finger protein 415 (ZNF415), mRNA.
AF038179 - Homo sapiens clone 23939 mRNA sequence.
BC063880 - Homo sapiens zinc finger protein 415, mRNA (cDNA clone MGC:75472 IMAGE:30388597), complete cds.
AK002053 - Homo sapiens cDNA FLJ11191 fis, clone PLACE1007598, weakly similar to ZINC FINGER PROTEIN 184.
JD468047 - Sequence 449071 from Patent EP1572962.
BC069668 - Homo sapiens zinc finger protein 415, mRNA (cDNA clone MGC:97368 IMAGE:7262632), complete cds.
JD150159 - Sequence 131183 from Patent EP1572962.
JD274490 - Sequence 255514 from Patent EP1572962.
JD434462 - Sequence 415486 from Patent EP1572962.
AB480247 - Homo sapiens Pact mRNA for hypothetical protein, partial cds.
KJ902880 - Synthetic construct Homo sapiens clone ccsbBroadEn_12274 ZNF415 gene, encodes complete protein.
EU446820 - Synthetic construct Homo sapiens clone IMAGE:100070112; IMAGE:100012029; FLH257519.01L zinc finger protein 415 (ZNF415) gene, encodes complete protein.
AB590458 - Synthetic construct DNA, clone: pFN21AE1162, Homo sapiens ZNF415 gene for zinc finger protein 415, without stop codon, in Flexi system.
LF344966 - JP 2014500723-A/152469: Polycomb-Associated Non-Coding RNAs.
MA580543 - JP 2018138019-A/152469: Polycomb-Associated Non-Coding RNAs.
JD047453 - Sequence 28477 from Patent EP1572962.
JD307267 - Sequence 288291 from Patent EP1572962.
JD314818 - Sequence 295842 from Patent EP1572962.
CU686965 - Synthetic construct Homo sapiens gateway clone IMAGE:100022687 5' read ZNF415 mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q09FC8 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001352148, Q09FC7, Q09FC8, Q09FC9, Q09FD0, Q6NSZ2, Q6P3S0, Q9NUR2, uc010ydt.1, uc010ydt.2, uc010ydt.3, ZN415_HUMAN
UCSC ID: uc010ydt.3
RefSeq Accession: NM_001136038
Protein: Q09FC8 (aka ZN415_HUMAN)
CCDS: CCDS12860.1, CCDS54313.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.