Human Gene ZDHHC11B (ENST00000508859.7) Description and Page Index
  Description: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. (from UniProt P0C7U3)
Gencode Transcript: ENST00000508859.7
Gencode Gene: ENSG00000206077.11
Transcript (Including UTRs)
   Position: hg38 chr5:711,808-784,729 Size: 72,922 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr5:716,808-766,919 Size: 50,112 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:711,808-784,729)mRNA (may differ from genome)Protein (371 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneCardsHGNCLynxMGIneXtProt
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZH11B_HUMAN
DESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC11B; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 11B; Short=DHHC-11B;
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.11 RPKM in Brain - Cerebellum
Total median expression: 270.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -110.70291-0.380 Picture PostScript Text
3' UTR -168.70482-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on P0C7U3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK096220 - Homo sapiens cDNA FLJ38901 fis, clone NT2NE2001040, moderately similar to Homo sapiens GL013 mRNA.
JD203103 - Sequence 184127 from Patent EP1572962.
JD176760 - Sequence 157784 from Patent EP1572962.
JD168867 - Sequence 149891 from Patent EP1572962.
JD457756 - Sequence 438780 from Patent EP1572962.
JD177287 - Sequence 158311 from Patent EP1572962.
JD176755 - Sequence 157779 from Patent EP1572962.
JD112962 - Sequence 93986 from Patent EP1572962.
JD467047 - Sequence 448071 from Patent EP1572962.
JD269802 - Sequence 250826 from Patent EP1572962.
JD239195 - Sequence 220219 from Patent EP1572962.
JD437281 - Sequence 418305 from Patent EP1572962.
JD154657 - Sequence 135681 from Patent EP1572962.
DQ590567 - Homo sapiens piRNA piR-57679, complete sequence.
JD411760 - Sequence 392784 from Patent EP1572962.
JD418344 - Sequence 399368 from Patent EP1572962.
JD435885 - Sequence 416909 from Patent EP1572962.
JD100643 - Sequence 81667 from Patent EP1572962.
JD162756 - Sequence 143780 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NHR3, JD435885, P0C7U3, uc063bxb.1, uc063bxb.2, ZH11B_HUMAN
UCSC ID: uc063bxb.2
RefSeq Accession: NR_147095
Protein: P0C7U3 (aka ZH11B_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.