Human Gene ZDHHC11B (ENST00000508859.7) Description and Page Index
  Description: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA. (from UniProt P0C7U3)
Gencode Transcript: ENST00000508859.7
Gencode Gene: ENSG00000206077.11
Transcript (Including UTRs)
   Position: hg38 chr5:711,808-784,729 Size: 72,922 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr5:716,808-766,919 Size: 50,112 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:711,808-784,729)mRNA (may differ from genome)Protein (371 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Probable palmitoyltransferase ZDHHC11B; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 11B; Short=DHHC-11B;
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.11 RPKM in Brain - Cerebellum
Total median expression: 270.43 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -110.70291-0.380 Picture PostScript Text
3' UTR -168.70482-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on P0C7U3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK096220 - Homo sapiens cDNA FLJ38901 fis, clone NT2NE2001040, moderately similar to Homo sapiens GL013 mRNA.
JD203103 - Sequence 184127 from Patent EP1572962.
JD176760 - Sequence 157784 from Patent EP1572962.
JD168867 - Sequence 149891 from Patent EP1572962.
JD457756 - Sequence 438780 from Patent EP1572962.
JD177287 - Sequence 158311 from Patent EP1572962.
JD176755 - Sequence 157779 from Patent EP1572962.
JD112962 - Sequence 93986 from Patent EP1572962.
JD467047 - Sequence 448071 from Patent EP1572962.
JD269802 - Sequence 250826 from Patent EP1572962.
JD239195 - Sequence 220219 from Patent EP1572962.
JD437281 - Sequence 418305 from Patent EP1572962.
JD154657 - Sequence 135681 from Patent EP1572962.
DQ590567 - Homo sapiens piRNA piR-57679, complete sequence.
JD411760 - Sequence 392784 from Patent EP1572962.
JD418344 - Sequence 399368 from Patent EP1572962.
JD435885 - Sequence 416909 from Patent EP1572962.
JD100643 - Sequence 81667 from Patent EP1572962.
JD162756 - Sequence 143780 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NHR3, JD435885, P0C7U3, uc063bxb.1, uc063bxb.2, ZH11B_HUMAN
UCSC ID: uc063bxb.2
RefSeq Accession: NR_147095
Protein: P0C7U3 (aka ZH11B_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.