Human Gene USP17L22 (ENST00000511280.1) Description and Page Index
  Description: Homo sapiens ubiquitin specific peptidase 17 like family member 22 (USP17L22), mRNA. (from RefSeq NM_001256863)
Gencode Transcript: ENST00000511280.1
Gencode Gene: ENSG00000248933.2
Transcript (Including UTRs)
   Position: hg38 chr4:9,267,619-9,269,211 Size: 1,593 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr4:9,267,619-9,269,211 Size: 1,593 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:9,267,619-9,269,211)mRNA (may differ from genome)Protein (530 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase; EC=;
CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
SIMILARITY: Belongs to the peptidase C19 family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006861 - HABP4_PAIRBP1-bd
IPR018200 - Pept_C19ubi-hydrolase_C_CS
IPR001394 - Peptidase_C19

Pfam Domains:
PF04774 - Hyaluronan / mRNA binding family
PF00443 - Ubiquitin carboxyl-terminal hydrolase

ModBase Predicted Comparative 3D Structure on D6RA61
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Cellular Component:
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum

-  Descriptions from all associated GenBank mRNAs
  BC156290 - Synthetic construct Homo sapiens clone IMAGE:100061686, MGC:190074 deubiquitinating enzyme 3 (DUB3) mRNA, encodes complete protein.
BC157073 - Synthetic construct Homo sapiens clone IMAGE:100063311, MGC:190736 deubiquitinating enzyme 3 (DUB3) mRNA, encodes complete protein.
LP896304 - Sequence 1168 from Patent EP3253886.
AY533200 - Homo sapiens deubiquitinating enzyme DUB4 mRNA, complete cds.
AF544011 - Homo sapiens deubiquitinating enzyme DUB1 (DUB1) mRNA, complete cds.
AF544012 - Homo sapiens deubiquitinating enzyme DUB2 (DUB2) mRNA, complete cds.
AY509884 - Homo sapiens deubiquitinating enzyme 3 (DUB3) mRNA, complete cds.
BC100991 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005796).
BC100992 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005797).
LF207810 - JP 2014500723-A/15313: Polycomb-Associated Non-Coding RNAs.
MA443387 - JP 2018138019-A/15313: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein D6RA61 (Reactome details) participates in the following event(s):

R-HSA-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
R-HSA-6782820 USP17 deubiquitinates SUDS3
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5688426 Deubiquitination
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: D6RA61, D6RA61_HUMAN, NM_001256863, uc031sdp.1
UCSC ID: uc031sdp.1
RefSeq Accession: NM_001256863
Protein: D6RA61 CCDS: CCDS59463.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.