Human Gene USP17L22 (ENST00000511280.1) Description and Page Index
  Description: Homo sapiens ubiquitin specific peptidase 17 like family member 22 (USP17L22), mRNA. (from RefSeq NM_001256863)
Gencode Transcript: ENST00000511280.1
Gencode Gene: ENSG00000248933.2
Transcript (Including UTRs)
   Position: hg38 chr4:9,267,619-9,269,211 Size: 1,593 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr4:9,267,619-9,269,211 Size: 1,593 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:9,267,619-9,269,211)mRNA (may differ from genome)Protein (530 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: D6RA61_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase; EC=3.4.19.12;
CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
SIMILARITY: Belongs to the peptidase C19 family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006861 - HABP4_PAIRBP1-bd
IPR018200 - Pept_C19ubi-hydrolase_C_CS
IPR001394 - Peptidase_C19

Pfam Domains:
PF04774 - Hyaluronan / mRNA binding family
PF00443 - Ubiquitin carboxyl-terminal hydrolase

ModBase Predicted Comparative 3D Structure on D6RA61
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Cellular Component:
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  BC156290 - Synthetic construct Homo sapiens clone IMAGE:100061686, MGC:190074 deubiquitinating enzyme 3 (DUB3) mRNA, encodes complete protein.
BC157073 - Synthetic construct Homo sapiens clone IMAGE:100063311, MGC:190736 deubiquitinating enzyme 3 (DUB3) mRNA, encodes complete protein.
LP896304 - Sequence 1168 from Patent EP3253886.
AY533200 - Homo sapiens deubiquitinating enzyme DUB4 mRNA, complete cds.
AF544011 - Homo sapiens deubiquitinating enzyme DUB1 (DUB1) mRNA, complete cds.
AF544012 - Homo sapiens deubiquitinating enzyme DUB2 (DUB2) mRNA, complete cds.
AY509884 - Homo sapiens deubiquitinating enzyme 3 (DUB3) mRNA, complete cds.
BC100991 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005796).
BC100992 - Homo sapiens deubiquitinating enzyme 3-like, mRNA (cDNA clone IMAGE:40005797).
LF207810 - JP 2014500723-A/15313: Polycomb-Associated Non-Coding RNAs.
MA443387 - JP 2018138019-A/15313: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein D6RA61 (Reactome details) participates in the following event(s):

R-HSA-5696600 USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
R-HSA-6782820 USP17 deubiquitinates SUDS3
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5688426 Deubiquitination
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: D6RA61, D6RA61_HUMAN, NM_001256863, uc031sdp.1
UCSC ID: uc031sdp.1
RefSeq Accession: NM_001256863
Protein: D6RA61 CCDS: CCDS59463.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.