Human Gene AMOTL2 (ENST00000514516.5) Description and Page Index
  Description: Homo sapiens angiomotin like 2 (AMOTL2), transcript variant 4, mRNA. (from RefSeq NM_001363943)
RefSeq Summary (NM_001278683): Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Gencode Transcript: ENST00000514516.5
Gencode Gene: ENSG00000114019.14
Transcript (Including UTRs)
   Position: hg38 chr3:134,355,877-134,375,479 Size: 19,603 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr3:134,357,705-134,375,300 Size: 17,596 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr3:134,355,877-134,375,479)mRNA (may differ from genome)Protein (837 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Angiomotin-like protein 2; AltName: Full=Leman coiled-coil protein; Short=LCCP;
FUNCTION: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
SUBUNIT: Interacts with SRC.
SUBCELLULAR LOCATION: Recycling endosome (By similarity).
PTM: Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway (By similarity).
SIMILARITY: Belongs to the angiomotin family.
SEQUENCE CAUTION: Sequence=AAH11454.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA76833.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD97318.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.07 RPKM in Cells - Transformed fibroblasts
Total median expression: 854.96 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.50179-0.310 Picture PostScript Text
3' UTR -574.801828-0.314 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009114 - Angiomotin
IPR024646 - Angiomotin_C

Pfam Domains:
PF12240 - Angiomotin C terminal

ModBase Predicted Comparative 3D Structure on Q9Y2J4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042802 identical protein binding

Biological Process:
GO:0016055 Wnt signaling pathway
GO:0035329 hippo signaling

Cellular Component:
GO:0005768 endosome
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0055037 recycling endosome

-  Descriptions from all associated GenBank mRNAs
  AB209077 - Homo sapiens mRNA for ribosomal protein L39 variant protein.
AB023206 - Homo sapiens Amotl2 mRNA for angiomotin like 2, other name:KIAA0989.
AF175966 - Homo sapiens angiomotin-like protein 2 (AMOTL2) mRNA, partial cds.
JD239571 - Sequence 220595 from Patent EP1572962.
AK074731 - Homo sapiens cDNA FLJ90250 fis, clone NT2RM4000100, highly similar to Angiomotin-like protein 2.
BC025981 - Homo sapiens angiomotin like 2, mRNA (cDNA clone IMAGE:3622128), complete cds.
BC011454 - Homo sapiens angiomotin like 2, mRNA (cDNA clone MGC:16955 IMAGE:4181482), complete cds.
JD305859 - Sequence 286883 from Patent EP1572962.
AK091040 - Homo sapiens cDNA FLJ33721 fis, clone BRAWH2016792, highly similar to Angiomotin-like protein 2.
JD433489 - Sequence 414513 from Patent EP1572962.
JD089663 - Sequence 70687 from Patent EP1572962.
JD557003 - Sequence 538027 from Patent EP1572962.
JD540579 - Sequence 521603 from Patent EP1572962.
JD501055 - Sequence 482079 from Patent EP1572962.
JD087459 - Sequence 68483 from Patent EP1572962.
JD470520 - Sequence 451544 from Patent EP1572962.
JD386514 - Sequence 367538 from Patent EP1572962.
JD206962 - Sequence 187986 from Patent EP1572962.
JD464899 - Sequence 445923 from Patent EP1572962.
JD233901 - Sequence 214925 from Patent EP1572962.
JD499479 - Sequence 480503 from Patent EP1572962.
JD130497 - Sequence 111521 from Patent EP1572962.
JD278560 - Sequence 259584 from Patent EP1572962.
JD111927 - Sequence 92951 from Patent EP1572962.
JD163040 - Sequence 144064 from Patent EP1572962.
JD272183 - Sequence 253207 from Patent EP1572962.
JD334138 - Sequence 315162 from Patent EP1572962.
JD492753 - Sequence 473777 from Patent EP1572962.
JD421256 - Sequence 402280 from Patent EP1572962.
JD197144 - Sequence 178168 from Patent EP1572962.
AK291616 - Homo sapiens cDNA FLJ75874 complete cds, highly similar to Homo sapiens angiomotin like 2 (AMOTL2), mRNA.
JD339907 - Sequence 320931 from Patent EP1572962.
JD557947 - Sequence 538971 from Patent EP1572962.
AK223598 - Homo sapiens mRNA for Angiomotin like 2 (Fragment) variant, clone: FCC131E02.
JD524628 - Sequence 505652 from Patent EP1572962.
JD418210 - Sequence 399234 from Patent EP1572962.
JD393719 - Sequence 374743 from Patent EP1572962.
JD391859 - Sequence 372883 from Patent EP1572962.
JD290298 - Sequence 271322 from Patent EP1572962.
JD421083 - Sequence 402107 from Patent EP1572962.
JD372801 - Sequence 353825 from Patent EP1572962.
AK299270 - Homo sapiens cDNA FLJ56142 complete cds, highly similar to Angiomotin-like protein 2.
AB384075 - Synthetic construct DNA, clone: pF1KSDA0989, Homo sapiens AMOTL2 gene for angiomotin-like protein 2, complete cds, without stop codon, in Flexi system.
KJ902591 - Synthetic construct Homo sapiens clone ccsbBroadEn_11985 AMOTL2 gene, encodes complete protein.
AK001343 - Homo sapiens cDNA FLJ10481 fis, clone NT2RP2000133, highly similar to Homo sapiens mRNA for KIAA0989 protein.
JD198247 - Sequence 179271 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2J4 (Reactome details) participates in the following event(s):

R-HSA-2028724 AMOT proteins bind YAP1
R-HSA-2028735 AMOT proteins bind WWTR1 (TAZ)
R-HSA-2028269 Signaling by Hippo
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6F1, AMOL2_HUMAN, B7Z5Q1, E9PHW3, KIAA0989, NM_001363943, Q53EP1, Q96F99, Q9UKB4, Q9Y2J4, uc003eqf.1, uc003eqf.2, uc003eqf.3, uc003eqf.4
UCSC ID: uc003eqf.4
RefSeq Accession: NM_001278683
Protein: Q9Y2J4 (aka AMOL2_HUMAN)
CCDS: CCDS63784.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.