Human Gene AMOTL2 (ENST00000514516.5) Description and Page Index
Description: Homo sapiens angiomotin like 2 (AMOTL2), transcript variant 4, mRNA. (from RefSeq NM_001363943) RefSeq Summary (NM_001278683): Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000514516.5 Gencode Gene: ENSG00000114019.14 Transcript (Including UTRs) Position: hg38 chr3:134,355,877-134,375,479 Size: 19,603 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr3:134,357,705-134,375,300 Size: 17,596 Coding Exon Count: 10
ID:AMOL2_HUMAN DESCRIPTION: RecName: Full=Angiomotin-like protein 2; AltName: Full=Leman coiled-coil protein; Short=LCCP; FUNCTION: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. SUBUNIT: Interacts with SRC. SUBCELLULAR LOCATION: Recycling endosome (By similarity). PTM: Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway (By similarity). SIMILARITY: Belongs to the angiomotin family. SEQUENCE CAUTION: Sequence=AAH11454.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA76833.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAD97318.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2J4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.