Human Gene OPCML (ENST00000524381.5) Description and Page Index
Description: Homo sapiens opioid binding protein/cell adhesion molecule like (OPCML), transcript variant 2, mRNA. (from RefSeq NM_001012393) RefSeq Summary (NM_001012393): This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. Gencode Transcript: ENST00000524381.5 Gencode Gene: ENSG00000183715.13 Transcript (Including UTRs) Position: hg38 chr11:132,414,981-133,532,519 Size: 1,117,539 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr11:132,420,193-133,532,324 Size: 1,112,132 Coding Exon Count: 8
ID:OPCM_HUMAN DESCRIPTION: RecName: Full=Opioid-binding protein/cell adhesion molecule; Short=OBCAM; Short=OPCML; Short=Opioid-binding cell adhesion molecule; AltName: Full=IgLON family member 1; Flags: Precursor; FUNCTION: Binds opioids in the presence of acidic lipids; probably involved in cell contact. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). DISEASE: Defects in OPCML are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/OPCMLID44423ch11q25.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14982
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.