Human Gene OPCML (ENST00000524381.5) Description and Page Index
  Description: Homo sapiens opioid binding protein/cell adhesion molecule like (OPCML), transcript variant 2, mRNA. (from RefSeq NM_001012393)
RefSeq Summary (NM_001012393): This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Gencode Transcript: ENST00000524381.5
Gencode Gene: ENSG00000183715.13
Transcript (Including UTRs)
   Position: hg38 chr11:132,414,981-133,532,519 Size: 1,117,539 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr11:132,420,193-133,532,324 Size: 1,112,132 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:132,414,981-133,532,519)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: OPCM_HUMAN
DESCRIPTION: RecName: Full=Opioid-binding protein/cell adhesion molecule; Short=OBCAM; Short=OPCML; Short=Opioid-binding cell adhesion molecule; AltName: Full=IgLON family member 1; Flags: Precursor;
FUNCTION: Binds opioids in the presence of acidic lipids; probably involved in cell contact.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).
DISEASE: Defects in OPCML are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late- stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
SIMILARITY: Belongs to the immunoglobulin superfamily. IgLON family.
SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/OPCMLID44423ch11q25.html";

-  MalaCards Disease Associations
  MalaCards Gene Search: OPCML
Diseases sorted by gene-association score: ovarian cancer, somatic* (1266), juvenile pilocytic astrocytoma (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.25 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 145.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.40195-0.294 Picture PostScript Text
3' UTR -1432.105212-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2

Pfam Domains:
PF07679 - Immunoglobulin I-set domain

ModBase Predicted Comparative 3D Structure on Q14982
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007155 cell adhesion
GO:0008038 neuron recognition

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX537377 - Homo sapiens mRNA; cDNA DKFZp686H1949 (from clone DKFZp686H1949); complete cds.
AK315859 - Homo sapiens cDNA, FLJ79508 complete cds, highly similar to Opioid-binding protein/cell adhesion moleculeprecursor.
AB529104 - Synthetic construct DNA, clone: pF1KB4518, Homo sapiens OPCML gene for opioid binding protein/cell adhesion molecule-like, without stop codon, in Flexi system.
BC117254 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:150863 IMAGE:40125805), complete cds.
BC126251 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:161529 IMAGE:8991967), complete cds.
BC143945 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:177480 IMAGE:9052463), complete cds.
BC143946 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:177481 IMAGE:9052464), complete cds.
AK299908 - Homo sapiens cDNA FLJ52276 complete cds, highly similar to Opioid-binding protein/cell adhesion molecule precursor.
L34774 - Human (clone pHOM) opioid-binding cell adhesion molecule mRNA, complete cds.
AK316273 - Homo sapiens cDNA, FLJ79172 complete cds, highly similar to Opioid-binding protein/cell adhesion moleculeprecursor.
AK299528 - Homo sapiens cDNA FLJ51061 complete cds, highly similar to Opioid-binding protein/cell adhesion molecule precursor.
AK289695 - Homo sapiens cDNA FLJ76211 complete cds, highly similar to Homo sapiens opioid binding protein/cell adhesion molecule-like(OPCML), mRNA.
AK316491 - Homo sapiens cDNA, FLJ79390 complete cds, highly similar to Opioid-binding protein/cell adhesion molecule precursor.
BC074742 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:104014 IMAGE:30915458), complete cds.
BC074773 - Homo sapiens opioid binding protein/cell adhesion molecule-like, mRNA (cDNA clone MGC:103819 IMAGE:30915200), complete cds.
EU562300 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 6 mRNA sequence, alternatively spliced.
EU562298 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 4 mRNA sequence, alternatively spliced.
EU562299 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 5 mRNA sequence, alternatively spliced.
EU562296 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 2 mRNA sequence, alternatively spliced.
AK314077 - Homo sapiens cDNA, FLJ94748.
EU562295 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 1 mRNA sequence, alternatively spliced.
EU562297 - Homo sapiens opioid binding protein/cell adhesion molecule-like transcript variant 3 mRNA sequence, alternatively spliced.
HQ258388 - Synthetic construct Homo sapiens clone IMAGE:100072817 Unknown protein gene, encodes complete protein.
KJ897278 - Synthetic construct Homo sapiens clone ccsbBroadEn_06672 OPCML gene, encodes complete protein.
KJ901615 - Synthetic construct Homo sapiens clone ccsbBroadEn_11009 OPCML gene, encodes complete protein.
AF070577 - Homo sapiens clone 24461 mRNA sequence.
AK125185 - Homo sapiens cDNA FLJ43195 fis, clone FEBRA2002456.
U79251 - Human clone 23878 mRNA sequence.
JD155126 - Sequence 136150 from Patent EP1572962.
JD339304 - Sequence 320328 from Patent EP1572962.
JD189584 - Sequence 170608 from Patent EP1572962.
JD080758 - Sequence 61782 from Patent EP1572962.
JD287908 - Sequence 268932 from Patent EP1572962.
JD073592 - Sequence 54616 from Patent EP1572962.
JD412288 - Sequence 393312 from Patent EP1572962.
JD190356 - Sequence 171380 from Patent EP1572962.
JD298032 - Sequence 279056 from Patent EP1572962.
JD067936 - Sequence 48960 from Patent EP1572962.
JD313467 - Sequence 294491 from Patent EP1572962.
JD303088 - Sequence 284112 from Patent EP1572962.
JD320211 - Sequence 301235 from Patent EP1572962.
JD039199 - Sequence 20223 from Patent EP1572962.
JD465093 - Sequence 446117 from Patent EP1572962.
JD349507 - Sequence 330531 from Patent EP1572962.
JD378873 - Sequence 359897 from Patent EP1572962.
JD113402 - Sequence 94426 from Patent EP1572962.
JD273544 - Sequence 254568 from Patent EP1572962.
JD163817 - Sequence 144841 from Patent EP1572962.
JD055970 - Sequence 36994 from Patent EP1572962.
JD399993 - Sequence 381017 from Patent EP1572962.
JD347222 - Sequence 328246 from Patent EP1572962.
JD518272 - Sequence 499296 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q14982 (Reactome details) participates in the following event(s):

R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: IGLON1, NM_001012393, OBCAM, OPCM_HUMAN, Q14982, Q17RN7, Q7Z3W6, uc001qgu.1, uc001qgu.2, uc001qgu.3, uc001qgu.4
UCSC ID: uc001qgu.4
RefSeq Accession: NM_001012393
Protein: Q14982 (aka OPCM_HUMAN)
CCDS: CCDS31722.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.