Human Gene ARHGAP42 (ENST00000524892.7) Description and Page Index
Description: Contains 1 PH domain. (from UniProt E9PJK4) RefSeq Summary (NM_152432): This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]. Gencode Transcript: ENST00000524892.7 Gencode Gene: ENSG00000165895.19 Transcript (Including UTRs) Position: hg38 chr11:100,687,653-100,993,941 Size: 306,289 Total Exon Count: 23 Strand: + Coding Region Position: hg38 chr11:100,687,679-100,988,801 Size: 301,123 Coding Exon Count: 23
ID:E9PJK4_HUMAN DESCRIPTION: SubName: Full=Rho GTPase-activating protein 42; SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 SH3 domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E9PJK4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.