Human Gene ARHGAP42 (ENST00000524892.7) Description and Page Index
  Description: Contains 1 PH domain. (from UniProt E9PJK4)
RefSeq Summary (NM_152432): This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017].
Gencode Transcript: ENST00000524892.7
Gencode Gene: ENSG00000165895.19
Transcript (Including UTRs)
   Position: hg38 chr11:100,687,653-100,993,941 Size: 306,289 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg38 chr11:100,687,679-100,988,801 Size: 301,123 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:100,687,653-100,993,941)mRNA (may differ from genome)Protein (840 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Rho GTPase-activating protein 42;
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 Rho-GAP domain.
SIMILARITY: Contains 1 SH3 domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D018817 N-Methyl-3,4-methylenedioxyamphetamine
  • C006253 pirinixic acid

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.39 RPKM in Nerve - Tibial
Total median expression: 68.30 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.5026-0.288 Picture PostScript Text
3' UTR -1244.405140-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013606 - IRSp53/MIM_homology_IMD
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR001452 - SH3_domain

Pfam Domains:
PF00620 - RhoGAP domain
PF00018 - SH3 domain

ModBase Predicted Comparative 3D Structure on E9PJK4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity

Biological Process:
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity

-  Descriptions from all associated GenBank mRNAs
  JD162365 - Sequence 143389 from Patent EP1572962.
AK057372 - Homo sapiens cDNA FLJ32810 fis, clone TESTI2002729, weakly similar to Homo sapiens mRNA for oligophrenin 1.
JD290340 - Sequence 271364 from Patent EP1572962.
DQ577449 - Homo sapiens piRNA piR-45561, complete sequence.
AK023666 - Homo sapiens cDNA FLJ13604 fis, clone PLACE1010401.
JD182894 - Sequence 163918 from Patent EP1572962.
JD284181 - Sequence 265205 from Patent EP1572962.
JD500135 - Sequence 481159 from Patent EP1572962.
AK314174 - Homo sapiens cDNA, FLJ94892, highly similar to Homo sapiens AD031 protein (AD031), mRNA.
AF247167 - Homo sapiens AD031 mRNA, complete cds.
JD092919 - Sequence 73943 from Patent EP1572962.
JD288021 - Sequence 269045 from Patent EP1572962.
BC112050 - Homo sapiens transmembrane protein 133, mRNA (cDNA clone MGC:138255 IMAGE:8327518), complete cds.
BC093843 - Homo sapiens transmembrane protein 133, mRNA (cDNA clone MGC:120878 IMAGE:7939688), complete cds.
BC058024 - Homo sapiens transmembrane protein 133, mRNA (cDNA clone IMAGE:4251720), with apparent retained intron.
JD508135 - Sequence 489159 from Patent EP1572962.
KJ894916 - Synthetic construct Homo sapiens clone ccsbBroadEn_04310 TMEM133 gene, encodes complete protein.
JD383420 - Sequence 364444 from Patent EP1572962.
JD114324 - Sequence 95348 from Patent EP1572962.
JD295037 - Sequence 276061 from Patent EP1572962.
JD046974 - Sequence 27998 from Patent EP1572962.
JD195144 - Sequence 176168 from Patent EP1572962.
JD347704 - Sequence 328728 from Patent EP1572962.
JD233681 - Sequence 214705 from Patent EP1572962.
JD181770 - Sequence 162794 from Patent EP1572962.
JD082574 - Sequence 63598 from Patent EP1572962.
JD376954 - Sequence 357978 from Patent EP1572962.
JD262696 - Sequence 243720 from Patent EP1572962.
JD353247 - Sequence 334271 from Patent EP1572962.
JD053916 - Sequence 34940 from Patent EP1572962.
JD295538 - Sequence 276562 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK023666, E9PJK4, E9PJK4_HUMAN, uc058gtm.1, uc058gtm.2
UCSC ID: uc058gtm.2
RefSeq Accession: NM_152432
Protein: E9PJK4

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.