Human Gene GRAMD1B (ENST00000529750.5) Description and Page Index
  Description: Homo sapiens GRAM domain containing 1B (GRAMD1B), transcript variant 2, mRNA. (from RefSeq NM_020716)
Gencode Transcript: ENST00000529750.5
Gencode Gene: ENSG00000023171.18
Transcript (Including UTRs)
   Position: hg38 chr11:123,525,822-123,627,774 Size: 101,953 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg38 chr11:123,526,149-123,622,595 Size: 96,447 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:123,525,822-123,627,774)mRNA (may differ from genome)Protein (738 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: GRM1B_HUMAN
DESCRIPTION: RecName: Full=GRAM domain-containing protein 1B;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 1 GRAM domain.
SEQUENCE CAUTION: Sequence=BAA86515.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 70.10 RPKM in Brain - Cerebellum
Total median expression: 344.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.40327-0.347 Picture PostScript Text
3' UTR -1790.305179-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004182 - GRAM

Pfam Domains:
PF02893 - GRAM domain

ModBase Predicted Comparative 3D Structure on Q3KR37
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK127457 - Homo sapiens cDNA FLJ45549 fis, clone BRTHA2036295.
LP895816 - Sequence 680 from Patent EP3253886.
BC105741 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone MGC:125624 IMAGE:40026783), complete cds.
BC105931 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone MGC:125622 IMAGE:40026781), complete cds.
BC105932 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone MGC:125623 IMAGE:40026782), complete cds.
BC107480 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone MGC:125625 IMAGE:40026784), complete cds.
KJ899341 - Synthetic construct Homo sapiens clone ccsbBroadEn_08735 GRAMD1B gene, encodes complete protein.
KJ899342 - Synthetic construct Homo sapiens clone ccsbBroadEn_08736 GRAMD1B gene, encodes complete protein.
AK297606 - Homo sapiens cDNA FLJ54653 complete cds.
AK307795 - Homo sapiens cDNA, FLJ97743.
AB033027 - Homo sapiens KIAA1201 mRNA for KIAA1201 protein.
AB384137 - Synthetic construct DNA, clone: pF1KSDA1201, Homo sapiens GRAMD1B gene for GRAM domain-containing protein 1B, complete cds, without stop codon, in Flexi system.
AY358924 - Homo sapiens clone DNA132162 PTSS3032 (UNQ3032) mRNA, complete cds.
JD528538 - Sequence 509562 from Patent EP1572962.
JD370023 - Sequence 351047 from Patent EP1572962.
JD099059 - Sequence 80083 from Patent EP1572962.
JD153548 - Sequence 134572 from Patent EP1572962.
JD428076 - Sequence 409100 from Patent EP1572962.
JD559486 - Sequence 540510 from Patent EP1572962.
JD342746 - Sequence 323770 from Patent EP1572962.
JD302565 - Sequence 283589 from Patent EP1572962.
JD560613 - Sequence 541637 from Patent EP1572962.
JD329504 - Sequence 310528 from Patent EP1572962.
JD549978 - Sequence 531002 from Patent EP1572962.
JD534652 - Sequence 515676 from Patent EP1572962.
JD398182 - Sequence 379206 from Patent EP1572962.
JD055078 - Sequence 36102 from Patent EP1572962.
JD418913 - Sequence 399937 from Patent EP1572962.
JD488478 - Sequence 469502 from Patent EP1572962.
JD299560 - Sequence 280584 from Patent EP1572962.
JD427446 - Sequence 408470 from Patent EP1572962.
JD466429 - Sequence 447453 from Patent EP1572962.
JD358787 - Sequence 339811 from Patent EP1572962.
JD154482 - Sequence 135506 from Patent EP1572962.
JD109776 - Sequence 90800 from Patent EP1572962.
JD114411 - Sequence 95435 from Patent EP1572962.
JD089073 - Sequence 70097 from Patent EP1572962.
JD206031 - Sequence 187055 from Patent EP1572962.
JD049184 - Sequence 30208 from Patent EP1572962.
JD344340 - Sequence 325364 from Patent EP1572962.
JD531045 - Sequence 512069 from Patent EP1572962.
JD180500 - Sequence 161524 from Patent EP1572962.
JD375518 - Sequence 356542 from Patent EP1572962.
JD080589 - Sequence 61613 from Patent EP1572962.
JD324617 - Sequence 305641 from Patent EP1572962.
JD109887 - Sequence 90911 from Patent EP1572962.
JD373462 - Sequence 354486 from Patent EP1572962.
JD436371 - Sequence 417395 from Patent EP1572962.
JD521829 - Sequence 502853 from Patent EP1572962.
JD460453 - Sequence 441477 from Patent EP1572962.
JD206698 - Sequence 187722 from Patent EP1572962.
JD463924 - Sequence 444948 from Patent EP1572962.
JD111922 - Sequence 92946 from Patent EP1572962.
JD424135 - Sequence 405159 from Patent EP1572962.
JD562243 - Sequence 543267 from Patent EP1572962.
JD128503 - Sequence 109527 from Patent EP1572962.
JD562011 - Sequence 543035 from Patent EP1572962.
BC075859 - Homo sapiens cDNA clone IMAGE:4358565, partial cds.
JD209768 - Sequence 190792 from Patent EP1572962.
BC063616 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone IMAGE:3847808).
JD454307 - Sequence 435331 from Patent EP1572962.
BC040970 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone IMAGE:3854666).
JD222189 - Sequence 203213 from Patent EP1572962.
JD490991 - Sequence 472015 from Patent EP1572962.
JD236835 - Sequence 217859 from Patent EP1572962.
JD043623 - Sequence 24647 from Patent EP1572962.
JD067881 - Sequence 48905 from Patent EP1572962.
JD194513 - Sequence 175537 from Patent EP1572962.
JD515683 - Sequence 496707 from Patent EP1572962.
JD039375 - Sequence 20399 from Patent EP1572962.
JD109301 - Sequence 90325 from Patent EP1572962.
JD260788 - Sequence 241812 from Patent EP1572962.
JD113415 - Sequence 94439 from Patent EP1572962.
JD262646 - Sequence 243670 from Patent EP1572962.
BC019049 - Homo sapiens, clone IMAGE:4584165, mRNA.
JD435942 - Sequence 416966 from Patent EP1572962.
JD091645 - Sequence 72669 from Patent EP1572962.
JD313882 - Sequence 294906 from Patent EP1572962.
JD514309 - Sequence 495333 from Patent EP1572962.
BC035131 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone IMAGE:5263798).
JD087871 - Sequence 68895 from Patent EP1572962.
JD177830 - Sequence 158854 from Patent EP1572962.
JD043545 - Sequence 24569 from Patent EP1572962.
BC011969 - Homo sapiens GRAM domain containing 1B, mRNA (cDNA clone IMAGE:3880654).

-  Other Names for This Gene
  Alternate Gene Symbols: GRM1B_HUMAN, KIAA1201, NM_020716, Q3KR37, Q6UW85, Q9ULL9, uc001pyx.1, uc001pyx.2, uc001pyx.3, uc001pyx.4, UNQ3032/PRO9834
UCSC ID: uc001pyx.4
RefSeq Accession: NM_020716
Protein: Q3KR37 (aka GRM1B_HUMAN)
CCDS: CCDS53720.1, CCDS66253.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.