Human Gene SELENOH (ENST00000534355.6) Description and Page Index
  Description: Homo sapiens selenoprotein H (SELENOH), transcript variant 1, mRNA. (from RefSeq NM_170746)
RefSeq Summary (NM_170746): This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016].
Gencode Transcript: ENST00000534355.6
Gencode Gene: ENSG00000211450.10
Transcript (Including UTRs)
   Position: hg38 chr11:57,741,491-57,743,550 Size: 2,060 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr11:57,741,596-57,742,217 Size: 622 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:57,741,491-57,743,550)mRNA (may differ from genome)Protein (122 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Selenoprotein H; Short=SelH;
FUNCTION: May be involved in a redox-related process (Potential).
SIMILARITY: Belongs to the SelWTH family.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 105.14 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2006.16 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.60105-0.320 Picture PostScript Text
3' UTR -209.30718-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011893 - Selenoprotein_Rdx-typ
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF10262 - Rdx family

ModBase Predicted Comparative 3D Structure on Q8IZQ5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding

-  Descriptions from all associated GenBank mRNAs
  BC111087 - Homo sapiens cDNA clone IMAGE:40030930.
AF536829 - Homo sapiens selenoprotein H mRNA, complete cds.
AJ276250 - Homo sapiens partial mRNA, clone c1-10h13.
AJ276249 - Homo sapiens partial mRNA, clone c1-10e16.
JD164448 - Sequence 145472 from Patent EP1572962.
BC064570 - Homo sapiens chromosome 11 open reading frame 31, mRNA (cDNA clone IMAGE:5590495), with apparent retained intron.
BC021122 - Homo sapiens chromosome 11 open reading frame 31, mRNA (cDNA clone MGC:31984 IMAGE:4766360), complete cds.
KJ895941 - Synthetic construct Homo sapiens clone ccsbBroadEn_05335 C11orf31-like gene, encodes complete protein.
JD345289 - Sequence 326313 from Patent EP1572962.
JD427174 - Sequence 408198 from Patent EP1572962.
AF085883 - Homo sapiens full length insert cDNA clone YP41H12.
JD264497 - Sequence 245521 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C11orf31, NM_170746, Q8IZQ5, Q8N672, SELH, SELH_HUMAN, uc021qjj.1, uc021qjj.2, uc021qjj.3
UCSC ID: uc021qjj.3
RefSeq Accession: NM_170746
Protein: Q8IZQ5 (aka SELH_HUMAN)
CCDS: CCDS44602.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.