Human Gene ATL3 (ENST00000538786.1) Description and Page Index
Description: Homo sapiens atlastin GTPase 3 (ATL3), transcript variant 2, mRNA. (from RefSeq NM_001290048) RefSeq Summary (NM_001290048): This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]. Gencode Transcript: ENST00000538786.1 Gencode Gene: ENSG00000184743.13 Transcript (Including UTRs) Position: hg38 chr11:63,629,253-63,671,909 Size: 42,657 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr11:63,629,319-63,659,244 Size: 29,926 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F5H6I7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.