Human Gene ZNF664 (ENST00000539644.5) Description and Page Index
  Description: May be involved in transcriptional regulation. (from UniProt Q8N3J9)
Gencode Transcript: ENST00000539644.5
Gencode Gene: ENSG00000179195.16
Transcript (Including UTRs)
   Position: hg38 chr12:123,973,123-124,015,422 Size: 42,300 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr12:124,012,145-124,012,930 Size: 786 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:123,973,123-124,015,422)mRNA (may differ from genome)Protein (261 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
LynxMGIneXtProtPubMedReactomeStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 664; AltName: Full=Zinc finger protein 176; AltName: Full=Zinc finger protein from organ of Corti;
FUNCTION: May be involved in transcriptional regulation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF664
Diseases sorted by gene-association score: deafness, autosomal dominant 41 (13), deafness, autosomal dominant 25 (12), clubfoot (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 65.19 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 1285.32 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -827.701830-0.452 Picture PostScript Text
3' UTR -672.102492-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q8N3J9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AL834266 - Homo sapiens mRNA; cDNA DKFZp761B128 (from clone DKFZp761B128).
BC051696 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:51237 IMAGE:5276234), complete cds.
BX647762 - Homo sapiens mRNA; cDNA DKFZp686M1851 (from clone DKFZp686M1851).
AK056034 - Homo sapiens cDNA FLJ31472 fis, clone NT2NE2001442, highly similar to Homo sapiens zinc finger protein 664 (ZNF664), mRNA.
JD223550 - Sequence 204574 from Patent EP1572962.
BC037793 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone IMAGE:4793237).
JD134222 - Sequence 115246 from Patent EP1572962.
JD211451 - Sequence 192475 from Patent EP1572962.
JD459004 - Sequence 440028 from Patent EP1572962.
JD089099 - Sequence 70123 from Patent EP1572962.
JD394813 - Sequence 375837 from Patent EP1572962.
JD390665 - Sequence 371689 from Patent EP1572962.
JD404065 - Sequence 385089 from Patent EP1572962.
JD248681 - Sequence 229705 from Patent EP1572962.
JD371112 - Sequence 352136 from Patent EP1572962.
JD498486 - Sequence 479510 from Patent EP1572962.
JD216766 - Sequence 197790 from Patent EP1572962.
JD452237 - Sequence 433261 from Patent EP1572962.
JD352590 - Sequence 333614 from Patent EP1572962.
JD524788 - Sequence 505812 from Patent EP1572962.
JD514515 - Sequence 495539 from Patent EP1572962.
JD371417 - Sequence 352441 from Patent EP1572962.
JD417041 - Sequence 398065 from Patent EP1572962.
JD070774 - Sequence 51798 from Patent EP1572962.
JD345718 - Sequence 326742 from Patent EP1572962.
JD345568 - Sequence 326592 from Patent EP1572962.
JD225391 - Sequence 206415 from Patent EP1572962.
JD225327 - Sequence 206351 from Patent EP1572962.
JD455848 - Sequence 436872 from Patent EP1572962.
JD391688 - Sequence 372712 from Patent EP1572962.
JD420617 - Sequence 401641 from Patent EP1572962.
JD280268 - Sequence 261292 from Patent EP1572962.
JD311449 - Sequence 292473 from Patent EP1572962.
BC017960 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:24083 IMAGE:4608465), complete cds.
JD434697 - Sequence 415721 from Patent EP1572962.
BC093848 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:120883 IMAGE:7939693), complete cds.
BC101530 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:126579 IMAGE:8069036), complete cds.
AB463374 - Synthetic construct DNA, clone: pF1KB8406, Homo sapiens ZNF664 gene for zinc finger protein 664, without stop codon, in Flexi system.
AM392806 - Synthetic construct Homo sapiens clone IMAGE:100001761 for hypothetical protein (ZNF664 gene).
EU446574 - Synthetic construct Homo sapiens clone IMAGE:100070181; IMAGE:100011783; FLH257305.01L zinc finger protein 664 (ZNF664) gene, encodes complete protein.
L41669 - Homo sapiens ZFOC1 mRNA, partial cds.
BC004339 - Homo sapiens cDNA clone IMAGE:3631961, **** WARNING: chimeric clone ****.
AF024695 - Homo sapiens clone L3-14 zinc finger protein mRNA, partial cds.
AK023009 - Homo sapiens cDNA FLJ12947 fis, clone NT2RP2005287.
JD203392 - Sequence 184416 from Patent EP1572962.
JD395020 - Sequence 376044 from Patent EP1572962.
JD302247 - Sequence 283271 from Patent EP1572962.
JD532901 - Sequence 513925 from Patent EP1572962.
JD444217 - Sequence 425241 from Patent EP1572962.
JD553523 - Sequence 534547 from Patent EP1572962.
JD250549 - Sequence 231573 from Patent EP1572962.
JD266328 - Sequence 247352 from Patent EP1572962.
JD221332 - Sequence 202356 from Patent EP1572962.
JD268242 - Sequence 249266 from Patent EP1572962.
JD047457 - Sequence 28481 from Patent EP1572962.
JD242400 - Sequence 223424 from Patent EP1572962.
JD471312 - Sequence 452336 from Patent EP1572962.
JD520438 - Sequence 501462 from Patent EP1572962.
JD207496 - Sequence 188520 from Patent EP1572962.
JD140906 - Sequence 121930 from Patent EP1572962.
JD469178 - Sequence 450202 from Patent EP1572962.
JD091107 - Sequence 72131 from Patent EP1572962.
JD225791 - Sequence 206815 from Patent EP1572962.
JD037266 - Sequence 18290 from Patent EP1572962.
JD359221 - Sequence 340245 from Patent EP1572962.
JD076953 - Sequence 57977 from Patent EP1572962.
JD367366 - Sequence 348390 from Patent EP1572962.
JD208193 - Sequence 189217 from Patent EP1572962.
JD299619 - Sequence 280643 from Patent EP1572962.
JD328157 - Sequence 309181 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N3J9 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: AL834266, B3KP97, Q15914, Q3ZCQ7, Q8N3J9, uc058uwb.1, ZFOC1, ZN664_HUMAN, ZNF196
UCSC ID: uc058uwb.1
RefSeq Accession: NM_152437
Protein: Q8N3J9 (aka ZN664_HUMAN)
CCDS: CCDS9257.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.