Human Gene SLC37A4 (ENST00000545985.5) Description and Page Index
  Description: Homo sapiens solute carrier family 37 member 4 (SLC37A4), transcript variant 1, mRNA. (from RefSeq NM_001164277)
RefSeq Summary (NM_001164277): This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289642.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000545985.5
Gencode Gene: ENSG00000137700.18
Transcript (Including UTRs)
   Position: hg38 chr11:119,024,351-119,030,906 Size: 6,556 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr11:119,024,910-119,029,369 Size: 4,460 Coding Exon Count: 9 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesGeneReviewsMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:119,024,351-119,030,906)mRNA (may differ from genome)Protein (429 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGImyGene2OMIMPubMedStanford SOURCE
UniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC37A4
Diseases sorted by gene-association score: glycogen storage disease ib* (1318), glycogen storage disease ic* (1300), glycogen storage disease ia* (368), glycogen storage disease (18), neutropenia (8)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.66 RPKM in Liver
Total median expression: 338.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -342.60757-0.453 Picture PostScript Text
3' UTR -187.30559-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AF111852 - Homo sapiens PRO0685 mRNA, complete cds.
Y15409 - Homo sapiens mRNA for putative glucose 6-phosphate translocase.
BC064563 - Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4, mRNA (cDNA clone MGC:74648 IMAGE:5580134), complete cds.
BC002400 - Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4, mRNA (cDNA clone MGC:8501 IMAGE:2822215), complete cds.
BC003589 - Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4, mRNA (cDNA clone MGC:4194 IMAGE:2822215), complete cds.
BC015650 - Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4, mRNA (cDNA clone MGC:23429 IMAGE:4660508), complete cds.
BC014663 - Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4, mRNA (cDNA clone MGC:23074 IMAGE:4857067), complete cds.
AB209026 - Homo sapiens mRNA for solute carrier family 37 (glycerol-6-phosphate transporter), member 4 variant protein.
JD265583 - Sequence 246607 from Patent EP1572962.
JD495656 - Sequence 476680 from Patent EP1572962.
JD466648 - Sequence 447672 from Patent EP1572962.
JD394175 - Sequence 375199 from Patent EP1572962.
JD146850 - Sequence 127874 from Patent EP1572962.
JD280351 - Sequence 261375 from Patent EP1572962.
AK298395 - Homo sapiens cDNA FLJ51721 complete cds, highly similar to Glucose-6-phosphate translocase.
JD195284 - Sequence 176308 from Patent EP1572962.
AK289642 - Homo sapiens cDNA FLJ78551 complete cds, highly similar to Homo sapiens solute carrier family 37 (glycerol-6-phosphate transporter), member 4 (SLC37A4), mRNA.
JD055338 - Sequence 36362 from Patent EP1572962.
JD145870 - Sequence 126894 from Patent EP1572962.
JD159718 - Sequence 140742 from Patent EP1572962.
JD163631 - Sequence 144655 from Patent EP1572962.
AK300646 - Homo sapiens cDNA FLJ51651 complete cds, highly similar to Glucose-6-phosphate translocase.
AF110819 - Homo sapiens glucose-6-phosphate translocase mRNA, complete cds.
AF110820 - Homo sapiens glucose-6-phosphate translocase mRNA, complete cds.
AF110821 - Homo sapiens glucose-6-phosphate translocase mRNA, sequence.
AF110822 - Homo sapiens glucose-6-phosphate translocase mRNA, sequence.
AY423732 - Homo sapiens transformation-related gene 19 protein mRNA, complete cds.
AK312628 - Homo sapiens cDNA, FLJ93012.
CR456733 - Homo sapiens full open reading frame cDNA clone RZPDo834B0411D for gene SLC37A4, solute carrier family 37 (glycerol-6-phosphate transporter), member 4; complete cds, incl. stopcodon.
HQ448291 - Synthetic construct Homo sapiens clone IMAGE:100071695; CCSB007595_04 solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4) gene, encodes complete protein.
KJ891208 - Synthetic construct Homo sapiens clone ccsbBroadEn_00602 SLC37A4 gene, encodes complete protein.
AK294993 - Homo sapiens cDNA FLJ51652 complete cds, highly similar to Glucose-6-phosphate translocase.
CU677381 - Synthetic construct Homo sapiens gateway clone IMAGE:100017249 5' read SLC37A4 mRNA.
JD277319 - Sequence 258343 from Patent EP1572962.
JD039113 - Sequence 20137 from Patent EP1572962.
JD128673 - Sequence 109697 from Patent EP1572962.
JD129682 - Sequence 110706 from Patent EP1572962.
JD405844 - Sequence 386868 from Patent EP1572962.
JD458634 - Sequence 439658 from Patent EP1572962.
JD544741 - Sequence 525765 from Patent EP1572962.
JD390032 - Sequence 371056 from Patent EP1572962.
JD231766 - Sequence 212790 from Patent EP1572962.
JD256219 - Sequence 237243 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001164277, U3KPU7, uc058idf.1
UCSC ID: uc058idf.1
RefSeq Accession: NM_001164277

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene SLC37A4:
gsd1 (Glycogen Storage Disease Type I)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.