Human Gene AC034102.2 (ENST00000548861.2) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H0YIN7)
RefSeq Summary (NM_006191): This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.127084.1, SRR1803611.137909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303305.11/ ENSP00000302886.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000548861.2
Gencode Gene: ENSG00000257411.2
Transcript (Including UTRs)
   Position: hg38 chr12:56,101,331-56,109,289 Size: 7,959 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr12:56,101,331-56,109,289 Size: 7,959 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMicroarray ExpressionProtein StructureOther Species
mRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:56,101,331-56,109,289)mRNA (may differ from genome)Protein (163 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneCardsMGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: H0YIN7_HUMAN
DESCRIPTION: SubName: Full=Uncharacterized protein; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000994 - Pept_M24_structural-domain
IPR018349 - Pept_M24A_MAP2_BS

Pfam Domains:
PF00557 - Metallopeptidase family M24

ModBase Predicted Comparative 3D Structure on H0YIN7
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  M34309 - Human epidermal growth factor receptor (HER3) mRNA, complete cds.
FW403754 - NUCLEIC ACID COMPOUNDS FOR INHIBITING ERBB FAMILY GENE EXPRESSION AND USES THEREOFF.
AK300909 - Homo sapiens cDNA FLJ53210 complete cds, highly similar to Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1).
AK294719 - Homo sapiens cDNA FLJ59207 complete cds, highly similar to Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1).
AK291681 - Homo sapiens cDNA FLJ76884 complete cds, highly similar to Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, mRNA.
BC082992 - Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), mRNA (cDNA clone MGC:88033 IMAGE:6147464), complete cds.
M29366 - Human epidermal growth factor receptor (ERBB3) mRNA, complete cds.
BC002706 - Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), mRNA (cDNA clone IMAGE:3629646), complete cds.
LF213765 - JP 2014500723-A/21268: Polycomb-Associated Non-Coding RNAs.
MA449342 - JP 2018138019-A/21268: Polycomb-Associated Non-Coding RNAs.
AK295650 - Homo sapiens cDNA FLJ55330 complete cds, highly similar to Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1).
BC041579 - Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), mRNA (cDNA clone IMAGE:4645144).
AK124710 - Homo sapiens cDNA FLJ42720 fis, clone BRAMY4000095, highly similar to Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1).
AK125028 - Homo sapiens cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1).
LF208962 - JP 2014500723-A/16465: Polycomb-Associated Non-Coding RNAs.
MA444539 - JP 2018138019-A/16465: Polycomb-Associated Non-Coding RNAs.
BC019222 - Homo sapiens proliferation-associated 2G4, 38kDa, mRNA (cDNA clone IMAGE:4281661), partial cds.
U87954 - Human erbB3 binding protein EBP1 mRNA, complete cds.
AK291796 - Homo sapiens cDNA FLJ75526 partial cds, highly similar to Homo sapiens proliferation-associated 2G4, 38kDa (PA2G4), mRNA.
BC007561 - Homo sapiens proliferation-associated 2G4, 38kDa, mRNA (cDNA clone MGC:15488 IMAGE:2988781), complete cds.
BC001951 - Homo sapiens proliferation-associated 2G4, 38kDa, mRNA (cDNA clone MGC:4383 IMAGE:2823726), complete cds.
BC011718 - Homo sapiens cDNA clone IMAGE:4099312, **** WARNING: chimeric clone ****.
BC032111 - Homo sapiens proliferation-associated 2G4, 38kDa, mRNA (cDNA clone IMAGE:4661091), partial cds.
BC087732 - Homo sapiens cDNA clone IMAGE:6253289, **** WARNING: chimeric clone ****.
BC072007 - Homo sapiens proliferation-associated 2G4, 38kDa, mRNA (cDNA clone IMAGE:6645910), partial cds.
U59435 - Human cell cycle protein p38-2G4 homolog (hG4-1) mRNA, complete cds.
BC069786 - Homo sapiens proliferation-associated 2G4, 38kDa, mRNA (cDNA clone MGC:97310 IMAGE:7262559), complete cds.
CU675707 - Synthetic construct Homo sapiens gateway clone IMAGE:100019216 5' read PA2G4 mRNA.
AB464072 - Synthetic construct DNA, clone: pF1KB8285, Homo sapiens PA2G4 gene for proliferation-associated 2G4, 38kDa, without stop codon, in Flexi system.
DQ893446 - Synthetic construct clone IMAGE:100006076; FLH199537.01X; RZPDo839H1082D proliferation-associated 2G4, 38kDa (PA2G4) gene, encodes complete protein.
DQ896751 - Synthetic construct Homo sapiens clone IMAGE:100011211; FLH199444.01L; RZPDo839H1081D proliferation-associated 2G4, 38kDa (PA2G4) gene, encodes complete protein.
KJ891745 - Synthetic construct Homo sapiens clone ccsbBroadEn_01139 PA2G4 gene, encodes complete protein.
U50137 - Human p38-2G4 mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CU675707, H0YIN7, H0YIN7_HUMAN, uc058phg.1, uc058phg.2
UCSC ID: uc058phg.2
RefSeq Accession: NM_006191
Protein: H0YIN7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.