Human Gene NR4A1 (ENST00000550082.5) Description and Page Index
Description: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. (from UniProt P22736) RefSeq Summary (NM_001202233): This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. Gencode Transcript: ENST00000550082.5 Gencode Gene: ENSG00000123358.20 Transcript (Including UTRs) Position: hg38 chr12:52,041,805-52,059,049 Size: 17,245 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr12:52,041,893-52,058,944 Size: 17,052 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22736
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0001938 positive regulation of endothelial cell proliferation GO:0002042 cell migration involved in sprouting angiogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007165 signal transduction GO:0030522 intracellular receptor signaling pathway GO:0035767 endothelial cell chemotaxis GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0043401 steroid hormone mediated signaling pathway GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045444 fat cell differentiation GO:0045786 negative regulation of cell cycle GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0061469 regulation of type B pancreatic cell proliferation GO:0071376 cellular response to corticotropin-releasing hormone stimulus