Human Gene DCN (ENST00000551354.1) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt F8VSI3)
RefSeq Summary (NM_133503): This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].
Gencode Transcript: ENST00000551354.1
Gencode Gene: ENSG00000011465.17
Transcript (Including UTRs)
   Position: hg38 chr12:91,175,118-91,179,533 Size: 4,416 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr12:91,177,534-91,178,552 Size: 1,019 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:91,175,118-91,179,533)mRNA (may differ from genome)Protein (100 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F8VSI3_HUMAN
DESCRIPTION: SubName: Full=Decorin;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: DCN
Diseases sorted by gene-association score: corneal dystrophy, congenital stromal* (1377), stromal dystrophy (24), interstitial keratitis (22), localized scleroderma (19), dupuytren contracture (13), neonatal marfan syndrome (13), eosinophilic granuloma (12), cornea plana (12), corneal dystrophy (11), pseudoachondroplasia (10), marfan syndrome (9), renal artery atheroma (9), peyronie's disease (8), gingival overgrowth (8), primary hypertrophic osteoarthropathy (8), crouzon syndrome (7), multiple epiphyseal dysplasia (6), achondrogenesis ib (6), odontogenic myxoma (5), tendinosis (4), nephrogenic systemic fibrosis (4), osseous heteroplasia, progressive (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 388.95 RPKM in Ovary
Total median expression: 5935.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.60205-0.227 Picture PostScript Text
3' UTR -541.102416-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000372 - LRR-contain_N

Pfam Domains:
PF01462 - Leucine rich repeat N-terminal domain

ModBase Predicted Comparative 3D Structure on F8VSI3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005518 collagen binding

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  KJ891032 - Synthetic construct Homo sapiens clone ccsbBroadEn_00426 DCN gene, encodes complete protein.
LF384686 - JP 2014500723-A/192189: Polycomb-Associated Non-Coding RNAs.
MA620263 - JP 2018138019-A/192189: Polycomb-Associated Non-Coding RNAs.
BX571756 - Homo sapiens mRNA; cDNA DKFZp686J19238 (from clone DKFZp686J19238).
AK291309 - Homo sapiens cDNA FLJ75936 complete cds, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA.
BC005322 - Homo sapiens decorin, mRNA (cDNA clone MGC:12406 IMAGE:3934022), complete cds.
M14219 - Human chondroitin/dermatan sulfate proteoglycan (PG40) core protein mRNA, complete cds.
AF138300 - Homo sapiens decorin variant A mRNA, complete cds.
AF138301 - Homo sapiens decorin B mRNA, complete cds, alternatively spliced.
AF138302 - Homo sapiens decorin variant C mRNA, complete cds.
AF138303 - Homo sapiens decorin D mRNA, complete cds, alternatively spliced.
CR541946 - Homo sapiens full open reading frame cDNA clone RZPDo834D1134D for gene DCN, decorin; complete cds, incl. stopcodon.
BT019800 - Homo sapiens decorin mRNA, complete cds.
DQ892556 - Synthetic construct clone IMAGE:100005186; FLH187471.01X; RZPDo839H0872D decorin (DCN) gene, encodes complete protein.
DQ895769 - Synthetic construct Homo sapiens clone IMAGE:100010229; FLH187467.01L; RZPDo839H0862D decorin (DCN) gene, encodes complete protein.
CR407676 - Homo sapiens full open reading frame cDNA clone RZPDo834C053D for gene DCN, decorin complete cds, without stopcodon.
KU178017 - Homo sapiens decorin isoform 1 (DCN) mRNA, partial cds.
KU178018 - Homo sapiens decorin isoform 2 (DCN) mRNA, partial cds, alternatively spliced.
KU178019 - Homo sapiens decorin isoform 3 (DCN) mRNA, complete cds, alternatively spliced.
KU178020 - Homo sapiens decorin isoform 4 (DCN) mRNA, complete cds, alternatively spliced.
AB463564 - Synthetic construct DNA, clone: pF1KB6509, Homo sapiens DCN gene for decorin, without stop codon, in Flexi system.
CU675109 - Synthetic construct Homo sapiens gateway clone IMAGE:100017098 5' read DCN mRNA.
AF138304 - Homo sapiens decorin variant E mRNA, complete cds.
AL355731 - Homo sapiens EST from clone 130486, 5' end.
LF323586 - JP 2014500723-A/131089: Polycomb-Associated Non-Coding RNAs.
MA559163 - JP 2018138019-A/131089: Polycomb-Associated Non-Coding RNAs.
JD023146 - Sequence 4170 from Patent EP1572962.
JD034857 - Sequence 15881 from Patent EP1572962.
JD249379 - Sequence 230403 from Patent EP1572962.
JD274120 - Sequence 255144 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04350 - TGF-beta signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_slrpPathway - Small Leucine-rich Proteoglycan (SLRP) molecules

-  Other Names for This Gene
  Alternate Gene Symbols: BX571756, F8VSI3, F8VSI3_HUMAN, uc058rqv.1
UCSC ID: uc058rqv.1
RefSeq Accession: NM_133503
Protein: F8VSI3

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene DCN:
csc-dys (Congenital Stromal Corneal Dystrophy)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.