Human Gene YPEL3 (ENST00000566595.5) Description and Page Index
  Description: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity). (from UniProt P61236)
Gencode Transcript: ENST00000566595.5
Gencode Gene: ENSG00000090238.12
Transcript (Including UTRs)
   Position: hg38 chr16:30,092,637-30,096,912 Size: 4,276 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr16:30,092,710-30,095,368 Size: 2,659 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:30,092,637-30,096,912)mRNA (may differ from genome)Protein (119 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein yippee-like 3;
FUNCTION: Involved in proliferation and apoptosis in myeloid precursor cells (By similarity).
SUBCELLULAR LOCATION: Nucleus, nucleolus.
TISSUE SPECIFICITY: Widely expressed.
PTM: Probably ubiquitinated leading to its degradation by the proteasome (By similarity).
SIMILARITY: Belongs to the yippee family.
SEQUENCE CAUTION: Sequence=EAW79925.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 127.56 RPKM in Whole Blood
Total median expression: 1916.71 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -150.90363-0.416 Picture PostScript Text
3' UTR -26.3073-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004910 - Yippee

Pfam Domains:
PF03226 - Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

ModBase Predicted Comparative 3D Structure on P61236
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:2000774 positive regulation of cellular senescence

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus

-  Descriptions from all associated GenBank mRNAs
  LF207899 - JP 2014500723-A/15402: Polycomb-Associated Non-Coding RNAs.
MA443476 - JP 2018138019-A/15402: Polycomb-Associated Non-Coding RNAs.
BC005009 - Homo sapiens yippee-like 3 (Drosophila), mRNA (cDNA clone MGC:10500 IMAGE:3639517), complete cds.
BC050664 - Homo sapiens yippee-like 3 (Drosophila), mRNA (cDNA clone MGC:60184 IMAGE:5748830), complete cds.
AB098737 - Homo sapiens YPEL3 mRNA for yippee-like 3, complete cds.
AF305622 - Homo sapiens DiGeorge syndrome-related protein FKSG5 mRNA, complete cds.
JD149208 - Sequence 130232 from Patent EP1572962.
JD517140 - Sequence 498164 from Patent EP1572962.
JD057083 - Sequence 38107 from Patent EP1572962.
JD282857 - Sequence 263881 from Patent EP1572962.
JD125042 - Sequence 106066 from Patent EP1572962.
KJ906353 - Synthetic construct Homo sapiens clone ccsbBroadEn_16023 YPEL3 gene, encodes complete protein.
KJ903359 - Synthetic construct Homo sapiens clone ccsbBroadEn_12753 YPEL3 gene, encodes complete protein.
AK026047 - Homo sapiens cDNA: FLJ22394 fis, clone HRC07882.
AK022409 - Homo sapiens cDNA FLJ12347 fis, clone MAMMA1002298.
LF369945 - JP 2014500723-A/177448: Polycomb-Associated Non-Coding RNAs.
MA605522 - JP 2018138019-A/177448: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC005009, FKSG5, P61236, Q65Z99, Q86VK6, Q9BSJ4, Q9CQB6, uc059taj.1, YPEL3_HUMAN
UCSC ID: uc059taj.1
RefSeq Accession: NM_001145524
Protein: P61236 (aka YPEL3_HUMAN or YPL3_HUMAN)
CCDS: CCDS45459.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.