Human Gene CRY2 (ENST00000616623.4) from GENCODE V38
  Description: cryptochrome circadian regulator 2 (from HGNC CRY2)
RefSeq Summary (NM_021117): This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gencode Transcript: ENST00000616623.4
Gencode Gene: ENSG00000121671.12
Transcript (Including UTRs)
   Position: hg38 chr11:45,847,406-45,883,248 Size: 35,843 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg38 chr11:45,847,428-45,872,231 Size: 24,804 Coding Exon Count: 11 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:45,847,406-45,883,248)mRNA (may differ from genome)Protein (614 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS

-  MalaCards Disease Associations
  MalaCards Gene Search: CRY2
Diseases sorted by gene-association score: western equine encephalitis (6), dysthymic disorder (5), major depressive disorder and accelerated response to antidepressant drug treatment (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.81 RPKM in Brain - Cerebellum
Total median expression: 1043.61 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.0022-0.182 Picture PostScript Text
3' UTR -894.402337-0.383 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  BC035161 - Homo sapiens cryptochrome 2 (photolyase-like), mRNA (cDNA clone MGC:43304 IMAGE:5265444), complete cds.
AK294904 - Homo sapiens cDNA FLJ53787 complete cds, highly similar to Homo sapiens cryptochrome 2 (photolyase-like) (CRY2), mRNA.
AK302865 - Homo sapiens cDNA FLJ54895 complete cds, highly similar to Homo sapiens cryptochrome 2 (photolyase-like) (CRY2), mRNA.
LF205782 - JP 2014500723-A/13285: Polycomb-Associated Non-Coding RNAs.
MA441359 - JP 2018138019-A/13285: Polycomb-Associated Non-Coding RNAs.
AK291260 - Homo sapiens cDNA FLJ75050 complete cds, highly similar to Homo sapiens cryptochrome 2 (photolyase-like) (CRY2), mRNA.
BC041814 - Homo sapiens cryptochrome 2 (photolyase-like), mRNA (cDNA clone MGC:43402 IMAGE:5266781), complete cds.
EU219622 - Homo sapiens growth-inhibiting protein 37 mRNA, complete cds.
AB014558 - Homo sapiens mRNA for KIAA0658 protein, partial cds.
LF205783 - JP 2014500723-A/13286: Polycomb-Associated Non-Coding RNAs.
MA441360 - JP 2018138019-A/13286: Polycomb-Associated Non-Coding RNAs.
AK295627 - Homo sapiens cDNA FLJ52645 complete cds, highly similar to Homo sapiens cryptochrome 2 (photolyase-like) (CRY2), mRNA.
AK001194 - Homo sapiens cDNA FLJ10332 fis, clone NT2RM2000636, highly similar to Homo sapiens mRNA for KIAA0658 protein.
CU692042 - Synthetic construct Homo sapiens gateway clone IMAGE:100021000 5' read CRY2 mRNA.
AB383943 - Synthetic construct DNA, clone: pF1KSDA0658, Homo sapiens CRY2 gene for cryptochrome-2, complete cds, without stop codon, in Flexi system.
JF432374 - Synthetic construct Homo sapiens clone IMAGE:100073571 cryptochrome 2 (photolyase-like) (CRY2) gene, encodes complete protein.
KJ901358 - Synthetic construct Homo sapiens clone ccsbBroadEn_10752 CRY2 gene, encodes complete protein.
LF348115 - JP 2014500723-A/155618: Polycomb-Associated Non-Coding RNAs.
MA583692 - JP 2018138019-A/155618: Polycomb-Associated Non-Coding RNAs.
JD100446 - Sequence 81470 from Patent EP1572962.
JD139187 - Sequence 120211 from Patent EP1572962.
JD025873 - Sequence 6897 from Patent EP1572962.
JD323320 - Sequence 304344 from Patent EP1572962.
JD361368 - Sequence 342392 from Patent EP1572962.
JD033609 - Sequence 14633 from Patent EP1572962.
JD466382 - Sequence 447406 from Patent EP1572962.
JD482471 - Sequence 463495 from Patent EP1572962.
JD526748 - Sequence 507772 from Patent EP1572962.
JD275409 - Sequence 256433 from Patent EP1572962.
JD519258 - Sequence 500282 from Patent EP1572962.
JD247176 - Sequence 228200 from Patent EP1572962.
JD190083 - Sequence 171107 from Patent EP1572962.
JD173093 - Sequence 154117 from Patent EP1572962.
JD117815 - Sequence 98839 from Patent EP1572962.
JD105044 - Sequence 86068 from Patent EP1572962.
JD473291 - Sequence 454315 from Patent EP1572962.
JD417519 - Sequence 398543 from Patent EP1572962.
JD411479 - Sequence 392503 from Patent EP1572962.
JD239568 - Sequence 220592 from Patent EP1572962.
JD118282 - Sequence 99306 from Patent EP1572962.
JD118283 - Sequence 99307 from Patent EP1572962.
JD339300 - Sequence 320324 from Patent EP1572962.
JD515066 - Sequence 496090 from Patent EP1572962.
JD108539 - Sequence 89563 from Patent EP1572962.
JD102427 - Sequence 83451 from Patent EP1572962.
JD431549 - Sequence 412573 from Patent EP1572962.
JD113386 - Sequence 94410 from Patent EP1572962.
JD556020 - Sequence 537044 from Patent EP1572962.
LF348107 - JP 2014500723-A/155610: Polycomb-Associated Non-Coding RNAs.
MA583684 - JP 2018138019-A/155610: Polycomb-Associated Non-Coding RNAs.
JD261390 - Sequence 242414 from Patent EP1572962.
JD402194 - Sequence 383218 from Patent EP1572962.
JD162686 - Sequence 143710 from Patent EP1572962.
JD403781 - Sequence 384805 from Patent EP1572962.
JD557057 - Sequence 538081 from Patent EP1572962.
JD383639 - Sequence 364663 from Patent EP1572962.
JD261351 - Sequence 242375 from Patent EP1572962.
JD531403 - Sequence 512427 from Patent EP1572962.
LF348106 - JP 2014500723-A/155609: Polycomb-Associated Non-Coding RNAs.
MA583683 - JP 2018138019-A/155609: Polycomb-Associated Non-Coding RNAs.
JD508068 - Sequence 489092 from Patent EP1572962.
JD433191 - Sequence 414215 from Patent EP1572962.
JD130508 - Sequence 111532 from Patent EP1572962.
JD145348 - Sequence 126372 from Patent EP1572962.
JD515086 - Sequence 496110 from Patent EP1572962.
JD325217 - Sequence 306241 from Patent EP1572962.
JD157950 - Sequence 138974 from Patent EP1572962.
JD469156 - Sequence 450180 from Patent EP1572962.
JD222990 - Sequence 204014 from Patent EP1572962.
JD213620 - Sequence 194644 from Patent EP1572962.
JD468032 - Sequence 449056 from Patent EP1572962.
JD051737 - Sequence 32761 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04710 - Circadian rhythm - mammal

BioCarta from NCI Cancer Genome Anatomy Project
h_circadianPathway - Circadian Rhythms

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0D2X7Z3, BC041814, ENST00000616623.1, ENST00000616623.2, ENST00000616623.3, uc010rgn.1, uc010rgn.2
UCSC ID: ENST00000616623.4
RefSeq Accession: NM_021117
CCDS: CCDS7915.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.