Human Gene POLR2A (ENST00000617998.5) Description and Page Index
  Description: RNA polymerase II subunit A (from HGNC POLR2A)
RefSeq Summary (NM_000937): This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X63564.1, BC137231.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000617998.5
Gencode Gene: ENSG00000181222.16
Transcript (Including UTRs)
   Position: hg38 chr17:7,484,366-7,514,616 Size: 30,251 Total Exon Count: 30 Strand: +
Coding Region
   Position: hg38 chr17:7,484,765-7,514,179 Size: 29,415 Coding Exon Count: 30 

Page IndexSequence and LinksMalaCardsCTDMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:7,484,366-7,514,616)mRNA (may differ from genome)Protein (1970 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: POLR2A
Diseases sorted by gene-association score: la crosse encephalitis (11), uv-sensitive syndrome (8), subcutaneous mycosis (7), herpes simplex (5), hiv-1 (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -164.30399-0.412 Picture PostScript Text
3' UTR -143.50437-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Descriptions from all associated GenBank mRNAs
  AK304882 - Homo sapiens cDNA FLJ61585 complete cds, highly similar to DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6).
LF209143 - JP 2014500723-A/16646: Polycomb-Associated Non-Coding RNAs.
MA444720 - JP 2018138019-A/16646: Polycomb-Associated Non-Coding RNAs.
AK293777 - Homo sapiens cDNA FLJ53860 complete cds, highly similar to DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6).
X63564 - H.sapiens mRNA for RNA polymerase II largest subunit.
JD360686 - Sequence 341710 from Patent EP1572962.
JD037458 - Sequence 18482 from Patent EP1572962.
LF326421 - JP 2014500723-A/133924: Polycomb-Associated Non-Coding RNAs.
MA561998 - JP 2018138019-A/133924: Polycomb-Associated Non-Coding RNAs.
JD404262 - Sequence 385286 from Patent EP1572962.
JD037143 - Sequence 18167 from Patent EP1572962.
BC137231 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, mRNA (cDNA clone MGC:168851 IMAGE:9021228), complete cds.
JD127182 - Sequence 108206 from Patent EP1572962.
BC067295 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, mRNA (cDNA clone IMAGE:30378439), complete cds.
CU688278 - Synthetic construct Homo sapiens gateway clone IMAGE:100023230 5' read POLR2A mRNA.
KJ901650 - Synthetic construct Homo sapiens clone ccsbBroadEn_11044 POLR2A gene, encodes complete protein.
LF326418 - JP 2014500723-A/133921: Polycomb-Associated Non-Coding RNAs.
MA561995 - JP 2018138019-A/133921: Polycomb-Associated Non-Coding RNAs.
LF326417 - JP 2014500723-A/133920: Polycomb-Associated Non-Coding RNAs.
MA561994 - JP 2018138019-A/133920: Polycomb-Associated Non-Coding RNAs.
M21610 - Human RNA polymerase II mRNA, 3' end of exon 5.
LF326416 - JP 2014500723-A/133919: Polycomb-Associated Non-Coding RNAs.
MA561993 - JP 2018138019-A/133919: Polycomb-Associated Non-Coding RNAs.
KX404973 - Homo sapiens isolate POLR2A_small_circ_F circular RNA circRNA, complete sequence.
LF326414 - JP 2014500723-A/133917: Polycomb-Associated Non-Coding RNAs.
MA561991 - JP 2018138019-A/133917: Polycomb-Associated Non-Coding RNAs.
LF326413 - JP 2014500723-A/133916: Polycomb-Associated Non-Coding RNAs.
MA561990 - JP 2018138019-A/133916: Polycomb-Associated Non-Coding RNAs.
LF326412 - JP 2014500723-A/133915: Polycomb-Associated Non-Coding RNAs.
MA561989 - JP 2018138019-A/133915: Polycomb-Associated Non-Coding RNAs.
LF326411 - JP 2014500723-A/133914: Polycomb-Associated Non-Coding RNAs.
MA561988 - JP 2018138019-A/133914: Polycomb-Associated Non-Coding RNAs.
LF326410 - JP 2014500723-A/133913: Polycomb-Associated Non-Coding RNAs.
MA561987 - JP 2018138019-A/133913: Polycomb-Associated Non-Coding RNAs.
LF209144 - JP 2014500723-A/16647: Polycomb-Associated Non-Coding RNAs.
MA444721 - JP 2018138019-A/16647: Polycomb-Associated Non-Coding RNAs.
LF326408 - JP 2014500723-A/133911: Polycomb-Associated Non-Coding RNAs.
MA561985 - JP 2018138019-A/133911: Polycomb-Associated Non-Coding RNAs.
LF326407 - JP 2014500723-A/133910: Polycomb-Associated Non-Coding RNAs.
MA561984 - JP 2018138019-A/133910: Polycomb-Associated Non-Coding RNAs.
LF326406 - JP 2014500723-A/133909: Polycomb-Associated Non-Coding RNAs.
MA561983 - JP 2018138019-A/133909: Polycomb-Associated Non-Coding RNAs.
LF326405 - JP 2014500723-A/133908: Polycomb-Associated Non-Coding RNAs.
MA561982 - JP 2018138019-A/133908: Polycomb-Associated Non-Coding RNAs.
LF326404 - JP 2014500723-A/133907: Polycomb-Associated Non-Coding RNAs.
MA561981 - JP 2018138019-A/133907: Polycomb-Associated Non-Coding RNAs.
LF326403 - JP 2014500723-A/133906: Polycomb-Associated Non-Coding RNAs.
MA561980 - JP 2018138019-A/133906: Polycomb-Associated Non-Coding RNAs.
LF326402 - JP 2014500723-A/133905: Polycomb-Associated Non-Coding RNAs.
MA561979 - JP 2018138019-A/133905: Polycomb-Associated Non-Coding RNAs.
LF326401 - JP 2014500723-A/133904: Polycomb-Associated Non-Coding RNAs.
MA561978 - JP 2018138019-A/133904: Polycomb-Associated Non-Coding RNAs.
LF326400 - JP 2014500723-A/133903: Polycomb-Associated Non-Coding RNAs.
MA561977 - JP 2018138019-A/133903: Polycomb-Associated Non-Coding RNAs.
LF326399 - JP 2014500723-A/133902: Polycomb-Associated Non-Coding RNAs.
MA561976 - JP 2018138019-A/133902: Polycomb-Associated Non-Coding RNAs.
LF326398 - JP 2014500723-A/133901: Polycomb-Associated Non-Coding RNAs.
MA561975 - JP 2018138019-A/133901: Polycomb-Associated Non-Coding RNAs.
JD200388 - Sequence 181412 from Patent EP1572962.
LF326397 - JP 2014500723-A/133900: Polycomb-Associated Non-Coding RNAs.
MA561974 - JP 2018138019-A/133900: Polycomb-Associated Non-Coding RNAs.
JD262480 - Sequence 243504 from Patent EP1572962.
JD136464 - Sequence 117488 from Patent EP1572962.
JD219356 - Sequence 200380 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism
hsa00240 - Pyrimidine metabolism
hsa01100 - Metabolic pathways
hsa03020 - RNA polymerase
hsa05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: uc060aps.1, uc060aps.2, uc060aps.3, X63564
UCSC ID: uc060aps.3
RefSeq Accession: NM_000937

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.