Human Gene AKAP9 (ENST00000619023.4) Description and Page Index
  Description: A-kinase anchoring protein 9 (from HGNC AKAP9)
RefSeq Summary (NM_147185): The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008].
Gencode Transcript: ENST00000619023.4
Gencode Gene: ENSG00000127914.16
Transcript (Including UTRs)
   Position: hg38 chr7:91,940,916-92,041,781 Size: 100,866 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg38 chr7:91,941,100-92,040,873 Size: 99,774 Coding Exon Count: 20 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesGeneReviews
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:91,940,916-92,041,781)mRNA (may differ from genome)Protein (1637 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: AKAP9
Diseases sorted by gene-association score: long qt syndrome-11* (1379), long qt syndrome 1* (129), long qt syndrome (12), skull base meningioma (9), skull base neoplasm (9), brugada syndrome* (7), cardiomyopathy, dilated, 1p (6), long qt syndrome 5 (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • D003300 Copper
  • C025205 1,10-phenanthroline
  • C023514 2,6-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C002166 4-methyl-7-diethylaminocoumarin
  • D015124 8-Bromo Cyclic Adenosine Monophosphate
  • D000086 Acetazolamide
  • D016604 Aflatoxin B1
  • D000393 Air Pollutants
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.11 RPKM in Pituitary
Total median expression: 283.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.50184-0.291 Picture PostScript Text
3' UTR -164.70908-0.181 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  KJ902063 - Synthetic construct Homo sapiens clone ccsbBroadEn_11457 AKAP9 gene, encodes complete protein.
AJ131693 - Homo sapiens mRNA for AKAP450 protein.
AF026245 - Homo sapiens yotiao mRNA, complete cds.
AB019691 - Homo sapiens mRNA for Centrosome- and Golgi-localized PKN-associated protein (CG-NAP), complete cds.
BC172915 - Synthetic construct Homo sapiens clone IMAGE:9094491 A-kinase anchor protein 9 isoform 3 (AKAP9) gene, partial cds.
AF247727 - Homo sapiens AKAP350C mRNA, complete cds, alternatively spliced.
AF083037 - Homo sapiens A-kinase anchoring protein AKAP350 mRNA, partial cds.
JD200882 - Sequence 181906 from Patent EP1572962.
BC015533 - Homo sapiens A kinase (PRKA) anchor protein (yotiao) 9, mRNA (cDNA clone IMAGE:3914749), complete cds.
JD407779 - Sequence 388803 from Patent EP1572962.
AY803272 - Homo sapiens AKAP9-BRAF fusion protein mRNA, complete cds.
JD095143 - Sequence 76167 from Patent EP1572962.
JD501388 - Sequence 482412 from Patent EP1572962.
CU677341 - Synthetic construct Homo sapiens gateway clone IMAGE:100022663 5' read AKAP9 mRNA.
JD240265 - Sequence 221289 from Patent EP1572962.
JD086675 - Sequence 67699 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_akapCentrosomePathway - Protein Kinase A at the Centrosome

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087WX84, AF026245, uc064fgf.1
UCSC ID: uc064fgf.1
RefSeq Accession: NM_147185

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene AKAP9:
rws (Long QT Syndrome)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.