Human Gene CYP4A22 (ENST00000619754.4) Description and Page Index
  Description: Homo sapiens cytochrome P450 family 4 subfamily A member 22 (CYP4A22), transcript variant 2, mRNA. (from RefSeq NM_001308102)
RefSeq Summary (NM_001308102): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gencode Transcript: ENST00000619754.4
Gencode Gene: ENSG00000162365.12
Transcript (Including UTRs)
   Position: hg38 chr1:47,137,454-47,147,402 Size: 9,949 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr1:47,137,486-47,146,157 Size: 8,672 Coding Exon Count: 9 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:47,137,454-47,147,402)mRNA (may differ from genome)Protein (357 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.70 RPKM in Liver
Total median expression: 52.57 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.4032-0.262 Picture PostScript Text
3' UTR -293.701245-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Descriptions from all associated GenBank mRNAs
  BC148248 - Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide 22, mRNA (cDNA clone MGC:165282 IMAGE:40132876), complete cds.
AY280371 - Homo sapiens cytochrome P450 4A22K (CYP4A22) mRNA, complete cds.
BC142690 - Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide 22, mRNA (cDNA clone MGC:165003 IMAGE:40148647), complete cds.
BC142607 - Homo sapiens cytochrome P450, family 4, subfamily A, polypeptide 22, mRNA (cDNA clone MGC:164744 IMAGE:40147121), complete cds.
KJ904137 - Synthetic construct Homo sapiens clone ccsbBroadEn_13531 CYP4A22 gene, encodes complete protein.
AY280372 - Homo sapiens cytochrome P450 4A22 (CYP4A22) mRNA, complete cds.
JD532322 - Sequence 513346 from Patent EP1572962.
JD526413 - Sequence 507437 from Patent EP1572962.
JD371618 - Sequence 352642 from Patent EP1572962.
JD110478 - Sequence 91502 from Patent EP1572962.
JD051279 - Sequence 32303 from Patent EP1572962.
JD436114 - Sequence 417138 from Patent EP1572962.
JD053155 - Sequence 34179 from Patent EP1572962.
JD184895 - Sequence 165919 from Patent EP1572962.
JD493360 - Sequence 474384 from Patent EP1572962.
JD146735 - Sequence 127759 from Patent EP1572962.
X71480 - H.sapiens Cyp4A-11 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00071 - Fatty acid metabolism
hsa00590 - Arachidonic acid metabolism
hsa00830 - Retinol metabolism
hsa01100 - Metabolic pathways
hsa03320 - PPAR signaling pathway
hsa04270 - Vascular smooth muscle contraction

BioCarta from NCI Cancer Genome Anatomy Project
h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087WZX9, NM_001308102, uc009vyp.1, uc009vyp.2, uc009vyp.3, uc009vyp.4
UCSC ID: uc009vyp.4
RefSeq Accession: NM_001308102
CCDS: CCDS76160.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.