Human Gene IRX5 (ENST00000620085.1) Description and Page Index
  Description: iroquois homeobox 5 (from HGNC IRX5)
RefSeq Summary (NM_001252197): This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gencode Transcript: ENST00000620085.1
Gencode Gene: ENSG00000176842.15
Transcript (Including UTRs)
   Position: hg38 chr16:54,931,199-54,933,960 Size: 2,762 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr16:54,931,199-54,933,520 Size: 2,322 Coding Exon Count: 4 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:54,931,199-54,933,960)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: IRX5
Diseases sorted by gene-association score: hamamy syndrome* (1678), griscelli syndrome, type 3 (5), obesity (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.42 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 66.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -150.40440-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on A2RRB5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  LF212220 - JP 2014500723-A/19723: Polycomb-Associated Non-Coding RNAs.
MA447797 - JP 2018138019-A/19723: Polycomb-Associated Non-Coding RNAs.
LF208224 - JP 2014500723-A/15727: Polycomb-Associated Non-Coding RNAs.
MA443801 - JP 2018138019-A/15727: Polycomb-Associated Non-Coding RNAs.
BC131510 - Homo sapiens iroquois homeobox 5, mRNA (cDNA clone IMAGE:40083630), complete cds.
AY335945 - Homo sapiens homeodomain protein IRXB2 (IRX5) mRNA, complete cds.
LF213136 - JP 2014500723-A/20639: Polycomb-Associated Non-Coding RNAs.
MA448713 - JP 2018138019-A/20639: Polycomb-Associated Non-Coding RNAs.
U90304 - Human iroquois-class homeodomain protein IRX-2a mRNA, complete cds.
JD131942 - Sequence 112966 from Patent EP1572962.
BC074850 - Homo sapiens iroquois homeobox 5, mRNA (cDNA clone IMAGE:30915566), with apparent retained intron.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRB5, A2RRB5_HUMAN, BC131510, uc059uhm.1
UCSC ID: uc059uhm.1
RefSeq Accession: NM_001252197
Protein: A2RRB5

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.