Human Gene IRX5 (ENST00000620085.1) Description and Page Index
Description: iroquois homeobox 5 (from HGNC IRX5) RefSeq Summary (NM_001252197): This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. Gencode Transcript: ENST00000620085.1 Gencode Gene: ENSG00000176842.15 Transcript (Including UTRs) Position: hg38 chr16:54,931,199-54,933,960 Size: 2,762 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr16:54,931,199-54,933,520 Size: 2,322 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on A2RRB5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.