Human Gene RAB11FIP4 (ENST00000621161.5) Description and Page Index
Description: Homo sapiens RAB11 family interacting protein 4 (RAB11FIP4), transcript variant 1, mRNA. (from RefSeq NM_032932) RefSeq Summary (NM_032932): The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]. Gencode Transcript: ENST00000621161.5 Gencode Gene: ENSG00000131242.18 Transcript (Including UTRs) Position: hg38 chr17:31,391,675-31,538,211 Size: 146,537 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr17:31,391,853-31,531,732 Size: 139,880 Coding Exon Count: 15
ID:RFIP4_HUMAN DESCRIPTION: RecName: Full=Rab11 family-interacting protein 4; Short=FIP4-Rab11; Short=Rab11-FIP4; AltName: Full=Arfophilin-2; FUNCTION: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. SUBUNIT: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECM29. SUBCELLULAR LOCATION: Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis. TISSUE SPECIFICITY: Present at high level in testis (at protein level). Weakly expressed in other tissues. DOMAIN: The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B) (By similarity). SIMILARITY: Contains 1 EF-hand domain. SIMILARITY: Contains 1 FIP-RBD domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86YS3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.