Human Gene RAB11FIP4 (ENST00000621161.5) Description and Page Index
  Description: Homo sapiens RAB11 family interacting protein 4 (RAB11FIP4), transcript variant 1, mRNA. (from RefSeq NM_032932)
RefSeq Summary (NM_032932): The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016].
Gencode Transcript: ENST00000621161.5
Gencode Gene: ENSG00000131242.18
Transcript (Including UTRs)
   Position: hg38 chr17:31,391,675-31,538,211 Size: 146,537 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chr17:31,391,853-31,531,732 Size: 139,880 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:31,391,675-31,538,211)mRNA (may differ from genome)Protein (637 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: RFIP4_HUMAN
DESCRIPTION: RecName: Full=Rab11 family-interacting protein 4; Short=FIP4-Rab11; Short=Rab11-FIP4; AltName: Full=Arfophilin-2;
FUNCTION: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
SUBUNIT: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Forms a heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with HCMV (human cytomegalovirus) gM/UL100. Interacts with ECM29.
SUBCELLULAR LOCATION: Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis.
TISSUE SPECIFICITY: Present at high level in testis (at protein level). Weakly expressed in other tissues.
DOMAIN: The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B) (By similarity).
SIMILARITY: Contains 1 EF-hand domain.
SIMILARITY: Contains 1 FIP-RBD domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.80178-0.589 Picture PostScript Text
3' UTR -2612.306479-0.403 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018249 - EF_HAND_2
IPR019018 - Rab-bd_FIP-RBD

Pfam Domains:
PF09457 - FIP domain

ModBase Predicted Comparative 3D Structure on Q86YS3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0030306 ADP-ribosylation factor binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0003407 neural retina development
GO:0016032 viral process
GO:0032465 regulation of cytokinesis
GO:1903452 positive regulation of G1 to G0 transition

Cellular Component:
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030139 endocytic vesicle
GO:0030496 midbody
GO:0031410 cytoplasmic vesicle
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane


-  Descriptions from all associated GenBank mRNAs
  AY169244 - Homo sapiens rab11-family interacting protein 4 mRNA, complete cds.
LF209220 - JP 2014500723-A/16723: Polycomb-Associated Non-Coding RNAs.
MA444797 - JP 2018138019-A/16723: Polycomb-Associated Non-Coding RNAs.
BC093914 - Homo sapiens RAB11 family interacting protein 4 (class II), mRNA (cDNA clone MGC:120949 IMAGE:7939759), complete cds.
BC101517 - Homo sapiens RAB11 family interacting protein 4 (class II), mRNA (cDNA clone MGC:126566 IMAGE:8069023), complete cds.
KJ899794 - Synthetic construct Homo sapiens clone ccsbBroadEn_09188 RAB11FIP4 gene, encodes complete protein.
AB058724 - Homo sapiens mRNA for KIAA1821 protein, partial cds.
AJ314646 - Homo sapiens partial mRNA for hypothetical protein and STS WI-9521.
LF212414 - JP 2014500723-A/19917: Polycomb-Associated Non-Coding RNAs.
MA447991 - JP 2018138019-A/19917: Polycomb-Associated Non-Coding RNAs.
JD462680 - Sequence 443704 from Patent EP1572962.
JD407388 - Sequence 388412 from Patent EP1572962.
JD217376 - Sequence 198400 from Patent EP1572962.
AK097424 - Homo sapiens cDNA FLJ40105 fis, clone TESTI2006383.
AK074060 - Homo sapiens mRNA for FLJ00131 protein.
AK074341 - Homo sapiens cDNA FLJ23761 fis, clone HEP18232.
AL831830 - Homo sapiens mRNA; cDNA DKFZp547F1714 (from clone DKFZp547F1714).
LF326922 - JP 2014500723-A/134425: Polycomb-Associated Non-Coding RNAs.
MA562499 - JP 2018138019-A/134425: Polycomb-Associated Non-Coding RNAs.
LF326924 - JP 2014500723-A/134427: Polycomb-Associated Non-Coding RNAs.
MA562501 - JP 2018138019-A/134427: Polycomb-Associated Non-Coding RNAs.
LF326925 - JP 2014500723-A/134428: Polycomb-Associated Non-Coding RNAs.
MA562502 - JP 2018138019-A/134428: Polycomb-Associated Non-Coding RNAs.
JD254163 - Sequence 235187 from Patent EP1572962.
JD181120 - Sequence 162144 from Patent EP1572962.
JD454598 - Sequence 435622 from Patent EP1572962.
LF326926 - JP 2014500723-A/134429: Polycomb-Associated Non-Coding RNAs.
MA562503 - JP 2018138019-A/134429: Polycomb-Associated Non-Coding RNAs.
JD191778 - Sequence 172802 from Patent EP1572962.
JD048801 - Sequence 29825 from Patent EP1572962.
JD205378 - Sequence 186402 from Patent EP1572962.
LF326927 - JP 2014500723-A/134430: Polycomb-Associated Non-Coding RNAs.
MA562504 - JP 2018138019-A/134430: Polycomb-Associated Non-Coding RNAs.
JD403703 - Sequence 384727 from Patent EP1572962.
JD286959 - Sequence 267983 from Patent EP1572962.
JD377001 - Sequence 358025 from Patent EP1572962.
JD142171 - Sequence 123195 from Patent EP1572962.
JD153448 - Sequence 134472 from Patent EP1572962.
JD162261 - Sequence 143285 from Patent EP1572962.
JD349044 - Sequence 330068 from Patent EP1572962.
JD501914 - Sequence 482938 from Patent EP1572962.
JD300976 - Sequence 282000 from Patent EP1572962.
JD252804 - Sequence 233828 from Patent EP1572962.
JD422888 - Sequence 403912 from Patent EP1572962.
JD422889 - Sequence 403913 from Patent EP1572962.
JD537175 - Sequence 518199 from Patent EP1572962.
JD416834 - Sequence 397858 from Patent EP1572962.
JD494408 - Sequence 475432 from Patent EP1572962.
JD288630 - Sequence 269654 from Patent EP1572962.
JD516522 - Sequence 497546 from Patent EP1572962.
JD355468 - Sequence 336492 from Patent EP1572962.
JD453051 - Sequence 434075 from Patent EP1572962.
JD039547 - Sequence 20571 from Patent EP1572962.
JD289894 - Sequence 270918 from Patent EP1572962.
JD368103 - Sequence 349127 from Patent EP1572962.
JD163422 - Sequence 144446 from Patent EP1572962.
AK055019 - Homo sapiens cDNA FLJ30457 fis, clone BRACE2009366.
JD163633 - Sequence 144657 from Patent EP1572962.
JD389556 - Sequence 370580 from Patent EP1572962.
JD390860 - Sequence 371884 from Patent EP1572962.
JD528634 - Sequence 509658 from Patent EP1572962.
JD363717 - Sequence 344741 from Patent EP1572962.
JD375654 - Sequence 356678 from Patent EP1572962.
JD165614 - Sequence 146638 from Patent EP1572962.
JD232849 - Sequence 213873 from Patent EP1572962.
LF326928 - JP 2014500723-A/134431: Polycomb-Associated Non-Coding RNAs.
MA562505 - JP 2018138019-A/134431: Polycomb-Associated Non-Coding RNAs.
JD439958 - Sequence 420982 from Patent EP1572962.
BC023618 - Homo sapiens RAB11 family interacting protein 4 (class II), mRNA (cDNA clone IMAGE:4652315), partial cds.
JD235670 - Sequence 216694 from Patent EP1572962.
LF326929 - JP 2014500723-A/134432: Polycomb-Associated Non-Coding RNAs.
MA562506 - JP 2018138019-A/134432: Polycomb-Associated Non-Coding RNAs.
JD294474 - Sequence 275498 from Patent EP1572962.
LF326930 - JP 2014500723-A/134433: Polycomb-Associated Non-Coding RNAs.
MA562507 - JP 2018138019-A/134433: Polycomb-Associated Non-Coding RNAs.
JD172407 - Sequence 153431 from Patent EP1572962.
JD287668 - Sequence 268692 from Patent EP1572962.
JD535173 - Sequence 516197 from Patent EP1572962.
BC004515 - Homo sapiens RAB11 family interacting protein 4 (class II), mRNA (cDNA clone IMAGE:3929435), partial cds.
JD436695 - Sequence 417719 from Patent EP1572962.
JD544137 - Sequence 525161 from Patent EP1572962.
JD485690 - Sequence 466714 from Patent EP1572962.
JD213978 - Sequence 195002 from Patent EP1572962.
JD371437 - Sequence 352461 from Patent EP1572962.
JD371438 - Sequence 352462 from Patent EP1572962.
JD403463 - Sequence 384487 from Patent EP1572962.
JD069530 - Sequence 50554 from Patent EP1572962.
JD293424 - Sequence 274448 from Patent EP1572962.
JD119416 - Sequence 100440 from Patent EP1572962.
JD273883 - Sequence 254907 from Patent EP1572962.
JD197915 - Sequence 178939 from Patent EP1572962.
JD095423 - Sequence 76447 from Patent EP1572962.
JD252511 - Sequence 233535 from Patent EP1572962.
JD119173 - Sequence 100197 from Patent EP1572962.
JD070904 - Sequence 51928 from Patent EP1572962.
JD379454 - Sequence 360478 from Patent EP1572962.
JD379456 - Sequence 360480 from Patent EP1572962.
JD379455 - Sequence 360479 from Patent EP1572962.
JD177675 - Sequence 158699 from Patent EP1572962.
HZ043039 - JP 2015510401-A/129: MESENCHYMAL STEM CELLS FOR IN VITRO MODELING AND CELL-BASED THERAPY OF HUMAN DISEASES AND BANKS THEREOF.
HZ081665 - JP 2015514392-A/129: MicroRNAS FOR THE GENERATION OF ASTROCYTES.
HZ409528 - JP 2015528002-A/2125: CHIRAL CONTROL.
LF404136 - JP 2015509366-A/129: GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS.
LG052862 - KR 1020150036642-A/2128: CHIRAL CONTROL.
MA353667 - JP 2018075017-A/129: GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS.
MP045307 - Sequence 129 from Patent EP3401394.
MP083977 - Sequence 129 from Patent EP3401393.
FR773005 - Homo sapiens microRNA hsa-miR-4724-3p.
HZ042964 - JP 2015510401-A/54: MESENCHYMAL STEM CELLS FOR IN VITRO MODELING AND CELL-BASED THERAPY OF HUMAN DISEASES AND BANKS THEREOF.
HZ081590 - JP 2015514392-A/54: MicroRNAS FOR THE GENERATION OF ASTROCYTES.
HZ481881 - JP 2015535430-A/2387: TERMINALLY MODIFIED RNA.
HZ791812 - JP 2016504050-A/3557: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC514544 - Sequence 4797 from Patent WO2014113089.
LF160628 - JP 2016513950-A/694: Oligomers with improved off-target profile.
LF404061 - JP 2015509366-A/54: GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS.
LQ072132 - Sequence 2456 from Patent EP2964234.
MA353592 - JP 2018075017-A/54: GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS.
MA645633 - JP 2017113010-A/3557: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA733517 - JP 2017140048-A/2387: TERMINALLY MODIFIED RNA.
MP015337 - Sequence 540 from Patent WO2019016252.
MP045232 - Sequence 54 from Patent EP3401394.
MP083902 - Sequence 54 from Patent EP3401393.
JD531086 - Sequence 512110 from Patent EP1572962.
JD321415 - Sequence 302439 from Patent EP1572962.
JD145774 - Sequence 126798 from Patent EP1572962.
JD431147 - Sequence 412171 from Patent EP1572962.
JD291466 - Sequence 272490 from Patent EP1572962.
JD129987 - Sequence 111011 from Patent EP1572962.
JD117137 - Sequence 98161 from Patent EP1572962.
AL359563 - Homo sapiens mRNA; cDNA DKFZp761C0747 (from clone DKFZp761C0747).
LF326931 - JP 2014500723-A/134434: Polycomb-Associated Non-Coding RNAs.
MA562508 - JP 2018138019-A/134434: Polycomb-Associated Non-Coding RNAs.
BC047674 - Homo sapiens RAB11 family interacting protein 4 (class II), mRNA (cDNA clone IMAGE:6050464).
LF326932 - JP 2014500723-A/134435: Polycomb-Associated Non-Coding RNAs.
MA562509 - JP 2018138019-A/134435: Polycomb-Associated Non-Coding RNAs.
BC094803 - Homo sapiens cDNA clone IMAGE:3957550.
BC006240 - Homo sapiens RAB11 family interacting protein 4 (class II), mRNA (cDNA clone IMAGE:3951532).
JD270428 - Sequence 251452 from Patent EP1572962.
MA802686 - JP 2018183181-A/3557: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04144 - Endocytosis

-  Other Names for This Gene
  Alternate Gene Symbols: ARFO2, KIAA1821, NM_032932, Q52LI1, Q86YS3, Q8N829, Q8NDT7, Q969D8, RFIP4_HUMAN, uc032fao.1, uc032fao.2, uc032fao.3
UCSC ID: uc032fao.3
RefSeq Accession: NM_032932
Protein: Q86YS3 (aka RFIP4_HUMAN)
CCDS: CCDS11267.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.