Human Gene KAZN (ENST00000636203.1) from GENCODE V38
  Description: kazrin, periplakin interacting protein (from HGNC KAZN)
RefSeq Summary (NM_201628): This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000636203.1
Gencode Gene: ENSG00000189337.17
Transcript (Including UTRs)
   Position: hg38 chr1:13,892,792-15,118,043 Size: 1,225,252 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg38 chr1:13,893,666-15,114,635 Size: 1,220,970 Coding Exon Count: 17 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:13,892,792-15,118,043)mRNA (may differ from genome)Protein (863 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.46 RPKM in Spleen
Total median expression: 342.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -417.20874-0.477 Picture PostScript Text
3' UTR -1276.703408-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Descriptions from all associated GenBank mRNAs
  AB028949 - Homo sapiens mRNA for KIAA1026 protein, partial cds.
AY505119 - Homo sapiens kazrin isoform A mRNA, complete cds.
AB384084 - Synthetic construct DNA, clone: pF1KSDA1026, Homo sapiens KIAA1026 gene for kazrin protein, complete cds, without stop codon, in Flexi system.
AY505120 - Homo sapiens kazrin isoform B mRNA, complete cds.
BC035501 - Homo sapiens kazrin, mRNA (cDNA clone MGC:20906 IMAGE:4556194), complete cds.
AY505121 - Homo sapiens kazrin isoform C mRNA, complete cds.
AK293806 - Homo sapiens cDNA FLJ58452 complete cds, weakly similar to Liprin-alpha.
AY505122 - Homo sapiens kazrin isoform D mRNA, complete cds.
CU690090 - Synthetic construct Homo sapiens gateway clone IMAGE:100021941 5' read KIAA1026 mRNA.
KJ893348 - Synthetic construct Homo sapiens clone ccsbBroadEn_02742 KAZN gene, encodes complete protein.
AB015329 - Homo sapiens HRIHFB2003 mRNA, partial cds.
BX648256 - Homo sapiens mRNA; cDNA DKFZp686D08115 (from clone DKFZp686D08115).
AK125794 - Homo sapiens cDNA FLJ43806 fis, clone TESTI4001100.
BC101637 - Homo sapiens kazrin, mRNA (cDNA clone IMAGE:8069143), complete cds.
BC113621 - Homo sapiens kazrin, mRNA (cDNA clone IMAGE:8322673), complete cds.
BC143641 - Homo sapiens kazrin, mRNA (cDNA clone IMAGE:9052155), complete cds.
HQ258111 - Synthetic construct Homo sapiens clone IMAGE:100072420 Unknown protein gene, encodes complete protein.
KJ902311 - Synthetic construct Homo sapiens clone ccsbBroadEn_11705 KAZN gene, encodes complete protein.
AK095631 - Homo sapiens cDNA FLJ38312 fis, clone FCBBF3021506.
AK125388 - Homo sapiens cDNA FLJ43398 fis, clone OCBBF2009836.
AK057155 - Homo sapiens cDNA FLJ32593 fis, clone SPLEN2000479.
AF052120 - Homo sapiens clone 23836 mRNA sequence.
JD133740 - Sequence 114764 from Patent EP1572962.
JD517361 - Sequence 498385 from Patent EP1572962.
JD555000 - Sequence 536024 from Patent EP1572962.
JD255687 - Sequence 236711 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A1B0GWK2, BX648256, uc285gbr.1
UCSC ID: ENST00000636203.1
RefSeq Accession: NM_201628

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.