Human Gene CNTN2 (ENST00000638378.1) Description and Page Index
Description: Homo sapiens contactin 2 (CNTN2), transcript variant 2, mRNA. (from RefSeq NM_001346083) RefSeq Summary (NM_001346083): This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000638378.1 Gencode Gene: ENSG00000184144.12 Transcript (Including UTRs) Position: hg38 chr1:205,042,968-205,074,928 Size: 31,961 Total Exon Count: 23 Strand: + Coding Region Position: hg38 chr1:205,053,186-205,073,765 Size: 20,580 Coding Exon Count: 22
ID:CNTN2_HUMAN DESCRIPTION: RecName: Full=Contactin-2; AltName: Full=Axonal glycoprotein TAG-1; AltName: Full=Axonin-1; AltName: Full=Transient axonal glycoprotein 1; Short=TAX-1; Flags: Precursor; FUNCTION: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons. SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin family. SIMILARITY: Contains 4 fibronectin type-III domains. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02246
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.