Human Gene OR1C1 (ENST00000641256.1) Description and Page Index
  Description: Odorant receptor (Potential). (from UniProt Q15619)
Gencode Transcript: ENST00000641256.1
Gencode Gene: ENSG00000221888.4
Transcript (Including UTRs)
   Position: hg38 chr1:247,754,846-247,760,556 Size: 5,711 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:247,757,462-247,758,406 Size: 945 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:247,754,846-247,760,556)mRNA (may differ from genome)Protein (314 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaCGAP
EnsemblExonPrimerGeneCardsHGNCHPRDLynx
MGIneXtProtPubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: OR1C1_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 1C1; AltName: Full=Olfactory receptor OR1-42; AltName: Full=Olfactory receptor TPCR27;
FUNCTION: Odorant receptor (Potential).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
SEQUENCE CAUTION: Sequence=DAA04763.1; Type=Erroneous initiation;
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR1C1";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.92 RPKM in Testis
Total median expression: 1.92 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.10158-0.216 Picture PostScript Text
3' UTR -544.802616-0.208 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

ModBase Predicted Comparative 3D Structure on Q15619
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC140914 - Homo sapiens olfactory receptor, family 1, subfamily C, member 1, mRNA (cDNA clone MGC:176591 IMAGE:9056726), complete cds.
AB529299 - Synthetic construct DNA, clone: pF1KE0883, Homo sapiens OR1C1 gene for olfactory receptor, family 1, subfamily C, member 1, without stop codon, in Flexi system.
X89674 - H.sapiens mRNA for TPCR27 protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15619 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B9EIR9, OR1C1_HUMAN, Q15619, Q5VVD2, Q6IF97, Q8NGZ1, Q96R83, uc010pza.1, uc010pza.2, uc010pza.3
UCSC ID: uc010pza.3
Protein: Q15619 (aka OR1C1_HUMAN or O1C1_HUMAN)
CCDS: CCDS41481.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.