ID:FNTA_MOUSE DESCRIPTION: RecName: Full=Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; EC=18.104.22.168; EC=22.214.171.124; AltName: Full=CAAX farnesyltransferase subunit alpha; AltName: Full=FTase-alpha; AltName: Full=Ras proteins prenyltransferase subunit alpha; AltName: Full=Type I protein geranyl-geranyltransferase subunit alpha; Short=GGTase-I-alpha; FUNCTION: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK. CATALYTIC ACTIVITY: Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate. CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. ENZYME REGULATION: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK. SUBUNIT: Heterodimer of an alpha and a beta subunit. Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA. PTM: Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. SIMILARITY: Belongs to the protein prenyltransferase subunit alpha family. SIMILARITY: Contains 5 PFTA repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q61239
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007528 neuromuscular junction development GO:0008284 positive regulation of cell proliferation GO:0010035 response to inorganic substance GO:0014070 response to organic cyclic compound GO:0018342 protein prenylation GO:0018343 protein farnesylation GO:0018344 protein geranylgeranylation GO:0034097 response to cytokine GO:0043066 negative regulation of apoptotic process GO:0045213 neurotransmitter receptor metabolic process GO:0045787 positive regulation of cell cycle GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process GO:0071340 skeletal muscle acetylcholine-gated channel clustering GO:0090044 positive regulation of tubulin deacetylation GO:0090045 positive regulation of deacetylase activity GO:0099601 regulation of neurotransmitter receptor activity