Mouse Gene Fnta (R13846) Description and Page Index
  Description: farnesyltransferase, CAAX box, alpha
Transcript (Including UTRs)
   Position: mm8 chr8:27,464,267-27,481,146 Size: 16,880 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm8 chr8:27,464,993-27,481,125 Size: 16,133 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2006-02-27

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:27,464,267-27,481,146)mRNA (may differ from genome)Protein (377 aa)
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-  Comments and Description Text from UniProtKB
  ID: FNTA_MOUSE
DESCRIPTION: RecName: Full=Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; EC=2.5.1.58; EC=2.5.1.59; AltName: Full=CAAX farnesyltransferase subunit alpha; AltName: Full=FTase-alpha; AltName: Full=Ras proteins prenyltransferase subunit alpha; AltName: Full=Type I protein geranyl-geranyltransferase subunit alpha; Short=GGTase-I-alpha;
FUNCTION: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK.
CATALYTIC ACTIVITY: Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
ENZYME REGULATION: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK.
SUBUNIT: Heterodimer of an alpha and a beta subunit. Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA.
PTM: Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA.
SIMILARITY: Belongs to the protein prenyltransferase subunit alpha family.
SIMILARITY: Contains 5 PFTA repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.2021-0.105 Picture PostScript Text
3' UTR -207.94726-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002088 - Prenyl_trans_a
IPR008940 - Prenyltransferase

Pfam Domains:
PF01239 - Protein prenyltransferase alpha subunit repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3PZ4
- X-ray


ModBase Predicted Comparative 3D Structure on Q61239
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
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Gene DetailsGene Details Gene DetailsGene DetailsGene Details
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GenBankRGDEnsemblFlyBaseWormBaseSGD
Protein Sequence Protein SequenceProtein SequenceProtein SequenceProtein Sequence
Alignment AlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004659 prenyltransferase activity
GO:0004660 protein farnesyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004662 CAAX-protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0008017 microtubule binding
GO:0008318 protein prenyltransferase activity
GO:0016740 transferase activity
GO:0030548 acetylcholine receptor regulator activity
GO:0030971 receptor tyrosine kinase binding
GO:0043014 alpha-tubulin binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0019840 isoprenoid binding
GO:0042277 peptide binding

Biological Process:
GO:0007528 neuromuscular junction development
GO:0008284 positive regulation of cell proliferation
GO:0010035 response to inorganic substance
GO:0014070 response to organic cyclic compound
GO:0018342 protein prenylation
GO:0018343 protein farnesylation
GO:0018344 protein geranylgeranylation
GO:0034097 response to cytokine
GO:0043066 negative regulation of apoptotic process
GO:0045213 neurotransmitter receptor metabolic process
GO:0045787 positive regulation of cell cycle
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090044 positive regulation of tubulin deacetylation
GO:0090045 positive regulation of deacetylase activity
GO:0099601 regulation of neurotransmitter receptor activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005953 CAAX-protein geranylgeranyltransferase complex
GO:0005965 protein farnesyltransferase complex


-  Descriptions from all associated GenBank mRNAs
  AK010744 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410089B03 product:farnesyltransferase, CAAX box, alpha, full insert sequence.
AK207560 - Mus musculus cDNA, clone:Y2G0108G11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016138, based on BLAT search.
D49744 - Mus musculus mRNA for farnesyltransferase alpha subunit, complete cds.
BC012711 - Mus musculus farnesyltransferase, CAAX box, alpha, mRNA (cDNA clone MGC:14009 IMAGE:4019240), complete cds.
AK153252 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830129K06 product:farnesyltransferase, CAAX box, alpha, full insert sequence.
AK090346 - Mus musculus 8 days neonate male testis cDNA, RIKEN full-length enriched library, clone:G630057C22 product:farnesyltransferase, CAAX box, alpha, full insert sequence.
AK184587 - Mus musculus cDNA, clone:Y0G0130M02, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016138, based on BLAT search.
AK183567 - Mus musculus cDNA, clone:Y0G0126G07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000016138, based on BLAT search.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q61239 (Reactome details) participates in the following event(s):

R-MMU-201640 Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha
R-MMU-2530501 FNTA:FNTB transfers FARN to GNGT1
R-MMU-111465 Apoptotic cleavage of cellular proteins
R-MMU-75153 Apoptotic execution phase
R-MMU-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-MMU-109581 Apoptosis
R-MMU-2514856 The phototransduction cascade
R-MMU-5357801 Programmed Cell Death
R-MMU-2187338 Visual phototransduction
R-MMU-418594 G alpha (i) signalling events
R-MMU-388396 GPCR downstream signalling
R-MMU-372790 Signaling by GPCR
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: AK010744, AK090346, AK153252, BC012711, D49744, FPTA, PGGT1A
UCSC ID: NM_008033
RefSeq Accession: NM_008033
Protein: Q61239 (aka FNTA_MOUSE)
CCDS: CCDS22205.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.