S. cerevisiae Gene ETR1 (YBR026C)
  Description: 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family localized to in mitochondria, where it has a probable role in fatty acid synthesis
Transcript (Including UTRs)
   Position: sacCer3 chrII:292,877-294,019 Size: 1,143 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrII:292,877-294,019 Size: 1,143 Coding Exon Count: 1 

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Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrII:292,877-294,019)mRNAProtein (380 aa)
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-  Comments and Description Text from UniProtKB
  ID: ETR1_YEAST
DESCRIPTION: RecName: Full=Enoyl-[acyl-carrier protein] reductase [NADPH, B-specific], mitochondrial; EC=1.3.1.10; AltName: Full=Mitochondrial respiratory function protein 1; AltName: Full=Trans-2-enoyl-CoA reductase; EC=1.3.1.38; Flags: Precursor;
FUNCTION: Required for respiration and the maintenance of the mitochondrial compartment. May have a role in the mitochondrial synthesis of fatty acids.
CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NADP(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADPH.
CATALYTIC ACTIVITY: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
SUBUNIT: Homodimer or in a complex with other proteins. Interacts with ARS1.
SUBCELLULAR LOCATION: Mitochondrion matrix.
MISCELLANEOUS: Present with 1560 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
CAUTION: Was originally (PubMed:8195160) thought to be a nuclear protein involved in transcriptional regulation of genes required for the functional assembly of mitochondrial respiratory proteins. This was later proven not to be the case (PubMed:11509667).

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002085 - ADH_SF_Zn-type
IPR011032 - GroES-like
IPR016040 - NAD(P)-bd_dom

ModBase Predicted Comparative 3D Structure on P38071
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
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