S. cerevisiae Gene STE6 (YKL209C)
  Description: Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells
Transcript (Including UTRs)
   Position: sacCer3 chrXI:42,423-46,295 Size: 3,873 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrXI:42,423-46,295 Size: 3,873 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrXI:42,423-46,295)mRNAProtein (1290 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Alpha-factor-transporting ATPase; EC=; AltName: Full=Mating factor A secretion protein STE6; AltName: Full=Multiple drug resistance protein homolog; AltName: Full=P-glycoprotein;
FUNCTION: STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone.
CATALYTIC ACTIVITY: ATP + H(2)O + alpha-factor(In) = ADP + phosphate + alpha-factor(Out).
INTERACTION: P40318:SSM4; NbExp=2; IntAct=EBI-18383, EBI-18208;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
PTM: Degraded via the ubiquitin system.
SIMILARITY: Belongs to the ABC transporter superfamily. Alpha- factor sex pheromone exporter (TC 3.A.1.206) family.
SIMILARITY: Contains 2 ABC transmembrane type-1 domains.
SIMILARITY: Contains 2 ABC transporter domains.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003593 - AAA+_ATPase
IPR003439 - ABC_transporter-like
IPR017871 - ABC_transporter_CS
IPR017940 - ABC_transporter_type1
IPR001140 - ABC_transptr_TM_dom
IPR011527 - ABC_transptrTM_dom_typ1

Pfam Domains:
PF00664 - ABC transporter transmembrane region
PF00005 - ABC transporter

ModBase Predicted Comparative 3D Structure on P12866
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
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