S. cerevisiae Gene ERG10 (YPL028W)
  Description: Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis
Transcript (Including UTRs)
   Position: sacCer3 chrXVI:498,096-499,292 Size: 1,197 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrXVI:498,096-499,292 Size: 1,197 Coding Exon Count: 1 

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Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrXVI:498,096-499,292)mRNAProtein (398 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Acetyl-CoA acetyltransferase; EC=; AltName: Full=Acetoacetyl-CoA thiolase; AltName: Full=Ergosterol biosynthesis protein 10;
FUNCTION: Catalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids.
CATALYTIC ACTIVITY: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.16 mM for CoA; KM=0.35 mM for acetoacetyl-CoA; pH dependence: Optimum pH is 8.8;
PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.
SUBUNIT: Multimeric.
INDUCTION: Induced by low intracellular sterol levels.
MISCELLANEOUS: Present with 60895 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the thiolase family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002155 - Thiolase
IPR016039 - Thiolase-like
IPR016038 - Thiolase-like_subgr
IPR020615 - Thiolase_acyl_enz_int_AS
IPR020610 - Thiolase_AS
IPR020617 - Thiolase_C
IPR020613 - Thiolase_CS
IPR020616 - Thiolase_N

Pfam Domains:
PF02803 - Thiolase, C-terminal domain
PF00108 - Thiolase, N-terminal domain

ModBase Predicted Comparative 3D Structure on P41338
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
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