S. cerevisiae Gene MRN1 (YPL184C)
  Description: RNA-binding protein proposed to be involved in translational regulation binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES)
Transcript (Including UTRs)
   Position: sacCer3 chrXVI:195,950-197,788 Size: 1,839 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrXVI:195,950-197,788 Size: 1,839 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrXVI:195,950-197,788)mRNAProtein (612 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RNA-binding protein MRN1; AltName: Full=Multicopy suppressor of RSC-NHP6 synthetic lethality protein 1; AltName: Full=Post-transcriptional regulator of 69 kDa;
FUNCTION: RNA-binding protein that binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES). Probably involved in translational regulation.
MISCELLANEOUS: Present with 7950 molecules/cell in log phase SD medium.
SIMILARITY: Contains 4 RRM (RNA recognition motif) domains.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

ModBase Predicted Comparative 3D Structure on Q08925
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
    Gene DetailsGene Details
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    Protein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006417 regulation of translation

Cellular Component:
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule

-  Other Names for This Gene
Protein: Q08925 (aka MRN1_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.