Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle. Transcript (Including UTRs) Position: ce6 chrII:14,652,461-14,666,846 Size: 14,386 Total Exon Count: 24 Strand: - Coding Region Position: ce6 chrII:14,652,461-14,666,755 Size: 14,295 Coding Exon Count: 24
ID:UNC52_CAEEL DESCRIPTION: RecName: Full=Basement membrane proteoglycan; AltName: Full=Perlecan homolog; AltName: Full=Uncoordinated protein 52; Short=Protein unc-52; Flags: Precursor; FUNCTION: Probable role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in muscle. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. TISSUE SPECIFICITY: Found in the basement membrane of all contractile tissues. It is concentrated over muscle dense bodies and M-lines which are associated with beta-integrin. DEVELOPMENTAL STAGE: Synthesized early in embryogenesis. SIMILARITY: Contains 16 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 7 laminin EGF-like domains. SIMILARITY: Contains 3 laminin G-like domains. SIMILARITY: Contains 2 laminin IV type A domains. SIMILARITY: Contains 3 LDL-receptor class A domains.
Pfam Domains: PF07679 - Immunoglobulin I-set domain PF00052 - Laminin B (Domain IV) PF00053 - Laminin EGF domain PF02210 - Laminin G domain PF00057 - Low-density lipoprotein receptor domain class A
ModBase Predicted Comparative 3D Structure on Q06561
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Human
Mouse
Rat
Zebrafish
D. melanogaster
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005198 structural molecule activity GO:0005509 calcium ion binding
Biological Process: GO:0002119 nematode larval development GO:0007005 mitochondrion organization GO:0007517 muscle organ development GO:0008543 fibroblast growth factor receptor signaling pathway GO:0009792 embryo development ending in birth or egg hatching GO:0016477 cell migration GO:0030239 myofibril assembly GO:0031581 hemidesmosome assembly GO:0040011 locomotion GO:0040017 positive regulation of locomotion GO:0046716 muscle cell cellular homeostasis GO:0048644 muscle organ morphogenesis GO:0060279 positive regulation of ovulation GO:0060298 positive regulation of sarcomere organization GO:0060465 pharynx development
US Server
