Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle. Transcript (Including UTRs) Position: ce6 chrII:14,652,461-14,666,846 Size: 14,386 Total Exon Count: 22 Strand: - Coding Region Position: ce6 chrII:14,652,461-14,666,755 Size: 14,295 Coding Exon Count: 22
ID:UNC52_CAEEL DESCRIPTION: RecName: Full=Basement membrane proteoglycan; AltName: Full=Perlecan homolog; AltName: Full=Uncoordinated protein 52; Short=Protein unc-52; Flags: Precursor; FUNCTION: Probable role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in muscle. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. TISSUE SPECIFICITY: Found in the basement membrane of all contractile tissues. It is concentrated over muscle dense bodies and M-lines which are associated with beta-integrin. DEVELOPMENTAL STAGE: Synthesized early in embryogenesis. SIMILARITY: Contains 16 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 7 laminin EGF-like domains. SIMILARITY: Contains 3 laminin G-like domains. SIMILARITY: Contains 2 laminin IV type A domains. SIMILARITY: Contains 3 LDL-receptor class A domains.
Pfam Domains: PF07679 - Immunoglobulin I-set domain PF00052 - Laminin B (Domain IV) PF00053 - Laminin EGF domain PF02210 - Laminin G domain PF00057 - Low-density lipoprotein receptor domain class A
ModBase Predicted Comparative 3D Structure on Q06561
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary