Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle. Transcript (Including UTRs) Position: ce6 chrII:14,647,267-14,666,846 Size: 19,580 Total Exon Count: 35 Strand: - Coding Region Position: ce6 chrII:14,647,382-14,666,755 Size: 19,374 Coding Exon Count: 35
ID:UNC52_CAEEL DESCRIPTION: RecName: Full=Basement membrane proteoglycan; AltName: Full=Perlecan homolog; AltName: Full=Uncoordinated protein 52; Short=Protein unc-52; Flags: Precursor; FUNCTION: Probable role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in muscle. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. TISSUE SPECIFICITY: Found in the basement membrane of all contractile tissues. It is concentrated over muscle dense bodies and M-lines which are associated with beta-integrin. DEVELOPMENTAL STAGE: Synthesized early in embryogenesis. SIMILARITY: Contains 16 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 7 laminin EGF-like domains. SIMILARITY: Contains 3 laminin G-like domains. SIMILARITY: Contains 2 laminin IV type A domains. SIMILARITY: Contains 3 LDL-receptor class A domains.
Pfam Domains: PF07679 - Immunoglobulin I-set domain PF00052 - Laminin B (Domain IV) PF00053 - Laminin EGF domain PF02210 - Laminin G domain PF00057 - Low-density lipoprotein receptor domain class A
ModBase Predicted Comparative 3D Structure on Q06561
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.