C. elegans Gene unc-52 (ZC101.2e)
  Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.
Transcript (Including UTRs)
   Position: ce6 chrII:14,647,267-14,666,846 Size: 19,580 Total Exon Count: 35 Strand: -
Coding Region
   Position: ce6 chrII:14,647,382-14,666,755 Size: 19,374 Coding Exon Count: 35 

Page IndexSequence and LinksUniProtKB CommentsPrimersProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2008-06-03

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrII:14,647,267-14,666,846)mRNAProtein (3375 aa)
Gene SorterGenome BrowserOther Species FASTAAlphaFoldPubMedRefSeq

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Basement membrane proteoglycan; AltName: Full=Perlecan homolog; AltName: Full=Uncoordinated protein 52; Short=Protein unc-52; Flags: Precursor;
FUNCTION: Probable role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in muscle.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
TISSUE SPECIFICITY: Found in the basement membrane of all contractile tissues. It is concentrated over muscle dense bodies and M-lines which are associated with beta-integrin.
DEVELOPMENTAL STAGE: Synthesized early in embryogenesis.
SIMILARITY: Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 7 laminin EGF-like domains.
SIMILARITY: Contains 3 laminin G-like domains.
SIMILARITY: Contains 2 laminin IV type A domains.
SIMILARITY: Contains 3 LDL-receptor class A domains.

-  Primer design for this transcript

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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR002049 - EGF_laminin
IPR009030 - Growth_fac_rcpt
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR018031 - Laminin_B_subgr
IPR000034 - Laminin_B_type_IV
IPR001791 - Laminin_G
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt

Pfam Domains:
PF07679 - Immunoglobulin I-set domain
PF00052 - Laminin B (Domain IV)
PF00053 - Laminin EGF domain
PF02210 - Laminin G domain
PF00057 - Low-density lipoprotein receptor domain class A

ModBase Predicted Comparative 3D Structure on Q06561
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene DetailsGene Details   
Gene SorterGene SorterGene Sorter   
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding

Biological Process:
GO:0002119 nematode larval development
GO:0007005 mitochondrion organization
GO:0007517 muscle organ development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009792 embryo development ending in birth or egg hatching
GO:0016477 cell migration
GO:0030239 myofibril assembly
GO:0031581 hemidesmosome assembly
GO:0040011 locomotion
GO:0040017 positive regulation of locomotion
GO:0046716 muscle cell cellular homeostasis
GO:0048644 muscle organ morphogenesis
GO:0060279 positive regulation of ovulation
GO:0060298 positive regulation of sarcomere organization
GO:0060465 pharynx development

Cellular Component:
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005737 cytoplasm
GO:0031012 extracellular matrix
GO:0031430 M band
GO:0055120 striated muscle dense body

-  Descriptions from all associated GenBank mRNAs
  AF132883 - Caenorhabditis elegans UNC-52/Perlecan (unc-52) mRNA, partial cds.

-  Other Names for This Gene
  WormBase ID: ZC101.2e
RefSeq Accession: NM_064643
Protein: Q06561 (aka UNC52_CAEEL or UN52_CAEEL)

-  WormBase Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.