C. elegans Gene unc-52 (ZC101.2e) Description and Page Index
  Description: The unc-52 gene encodes perlecan, a protein orthologous to human basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2; OMIM:142461, which when mutated leads to Schwartz-Jampel syndrome or dyssegmental dysplasia); UNC-52 plays essential roles in muscle structure development and regulation of growth factor-like signaling pathways; UNC-52 is synthesized by the hypodermis and localizes to the extracellular matrix between hypodermis and muscle.
Transcript (Including UTRs)
   Position: ce6 chrII:14,647,267-14,666,846 Size: 19,580 Total Exon Count: 35 Strand: -
Coding Region
   Position: ce6 chrII:14,647,382-14,666,755 Size: 19,374 Coding Exon Count: 35 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated: 2008-06-03

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrII:14,647,267-14,666,846)mRNAProtein (3375 aa)
Gene SorterGenome BrowserOther Species FASTAPubMedRefSeqUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Basement membrane proteoglycan; AltName: Full=Perlecan homolog; AltName: Full=Uncoordinated protein 52; Short=Protein unc-52; Flags: Precursor;
FUNCTION: Probable role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in muscle.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
TISSUE SPECIFICITY: Found in the basement membrane of all contractile tissues. It is concentrated over muscle dense bodies and M-lines which are associated with beta-integrin.
DEVELOPMENTAL STAGE: Synthesized early in embryogenesis.
SIMILARITY: Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
SIMILARITY: Contains 7 laminin EGF-like domains.
SIMILARITY: Contains 3 laminin G-like domains.
SIMILARITY: Contains 2 laminin IV type A domains.
SIMILARITY: Contains 3 LDL-receptor class A domains.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR000742 - EG-like_dom
IPR013032 - EGF-like_CS
IPR002049 - EGF_laminin
IPR009030 - Growth_fac_rcpt
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR018031 - Laminin_B_subgr
IPR000034 - Laminin_B_type_IV
IPR001791 - Laminin_G
IPR023415 - LDLR_class-A_CS
IPR002172 - LDrepeatLR_classA_rpt

Pfam Domains:
PF07679 - Immunoglobulin I-set domain
PF00052 - Laminin B (Domain IV)
PF00053 - Laminin EGF domain
PF02210 - Laminin G domain
PF00057 - Low-density lipoprotein receptor domain class A

ModBase Predicted Comparative 3D Structure on Q06561
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
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