Human Gene SDF4 (ENST00000263741.12) from GENCODE V44
  Description: Homo sapiens stromal cell derived factor 4 (SDF4), transcript variant 1, mRNA. (from RefSeq NM_016547)
RefSeq Summary (NM_016547): This gene encodes a stromal cell derived factor that is a member of the CREC protein family. The encoded protein contains six EF-hand motifs and calcium-binding motifs. This protein localizes to the Golgi lumen and may be involved in regulating calcium dependent cellular activities. [provided by RefSeq, Sep 2011].
Gencode Transcript: ENST00000263741.12
Gencode Gene: ENSG00000078808.20
Transcript (Including UTRs)
   Position: hg38 chr1:1,216,931-1,232,031 Size: 15,101 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr1:1,217,670-1,228,772 Size: 11,103 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,216,931-1,232,031)mRNA (may differ from genome)Protein (341 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SDF4
Diseases sorted by gene-association score: bladder squamous cell carcinoma (2), cardiomyopathy, dilated, 1p (1), myopathy, tubular aggregate, 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 89.68 RPKM in Cells - Cultured fibroblasts
Total median expression: 2886.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.20314-0.402 Picture PostScript Text
3' UTR -310.50739-0.420 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK000717 - Homo sapiens cDNA FLJ20710 fis, clone KAIA1109.
BC022375 - Homo sapiens stromal cell derived factor 4, mRNA (cDNA clone MGC:23934 IMAGE:4839718), complete cds.
BC008917 - Homo sapiens stromal cell derived factor 4, mRNA (cDNA clone MGC:16111 IMAGE:3622725), complete cds.
AK027277 - Homo sapiens cDNA FLJ14371 fis, clone HEMBA1001302, highly similar to Homo sapiens calcium binding protein precursor, mRNA.
AK222521 - Homo sapiens mRNA for calcium binding protein Cab45 precursor variant, clone: adSE01609.
AK075352 - Homo sapiens cDNA PSEC0034 fis, clone NT2RP1000713, highly similar to 45 KDA CALCIUM-BINDING PROTEIN PRECURSOR.
BC007625 - Homo sapiens stromal cell derived factor 4, mRNA (cDNA clone MGC:15780 IMAGE:3503540), complete cds.
BC011244 - Homo sapiens stromal cell derived factor 4, mRNA (cDNA clone MGC:18132 IMAGE:4153655), complete cds.
BC006211 - Homo sapiens stromal cell derived factor 4, mRNA (cDNA clone MGC:852 IMAGE:3162764), complete cds.
AF153686 - Homo sapiens calcium binding protein precursor, mRNA, complete cds.
AF178986 - Homo sapiens calcium binding protein Cab45 precursor, mRNA, complete cds.
AK126927 - Homo sapiens cDNA FLJ44980 fis, clone BRAWH3003573, highly similar to 45 kDa calcium-binding protein precursor (Stromal cell-derived factor 4) (SDF-4).
AK055331 - Homo sapiens cDNA FLJ30769 fis, clone FEBRA2000733, highly similar to 45 KDA CALCIUM-BINDING PROTEIN PRECURSOR.
JD384544 - Sequence 365568 from Patent EP1572962.
JD054014 - Sequence 35038 from Patent EP1572962.
JD396996 - Sequence 378020 from Patent EP1572962.
JD415624 - Sequence 396648 from Patent EP1572962.
JD210440 - Sequence 191464 from Patent EP1572962.
JD391930 - Sequence 372954 from Patent EP1572962.
JD129602 - Sequence 110626 from Patent EP1572962.
AK223079 - Homo sapiens mRNA for calcium binding protein Cab45 precursor variant, clone: KAT02235.
JD021082 - Sequence 2106 from Patent EP1572962.
JD020639 - Sequence 1663 from Patent EP1572962.
JD023101 - Sequence 4125 from Patent EP1572962.
JD033391 - Sequence 14415 from Patent EP1572962.
L79912 - Homo sapiens EF-hand calcium-binding protein of 45 kDa mRNA, complete cds.
AK315517 - Homo sapiens cDNA, FLJ96583, highly similar to Homo sapiens stromal cell derived factor 4 (SDF4), mRNA.
AF132749 - Homo sapiens calcium-binding protein Cab45b mRNA, complete cds.
HQ448229 - Synthetic construct Homo sapiens clone IMAGE:100071630; CCSB000374_02 stromal cell derived factor 4 (SDF4) gene, encodes complete protein.
KJ898839 - Synthetic construct Homo sapiens clone ccsbBroadEn_08233 SDF4 gene, encodes complete protein.
JD322776 - Sequence 303800 from Patent EP1572962.
JD075294 - Sequence 56318 from Patent EP1572962.
CU679896 - Synthetic construct Homo sapiens gateway clone IMAGE:100017107 5' read SDF4 mRNA.
AK299810 - Homo sapiens cDNA FLJ59162 complete cds, highly similar to 45 kDa calcium-binding protein precursor.
JD114782 - Sequence 95806 from Patent EP1572962.
JD419348 - Sequence 400372 from Patent EP1572962.
JD372732 - Sequence 353756 from Patent EP1572962.
JD103975 - Sequence 84999 from Patent EP1572962.
JD155149 - Sequence 136173 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A5F9UJX7, ENST00000263741.1, ENST00000263741.10, ENST00000263741.11, ENST00000263741.2, ENST00000263741.3, ENST00000263741.4, ENST00000263741.5, ENST00000263741.6, ENST00000263741.7, ENST00000263741.8, ENST00000263741.9, NM_016547, uc001adi.1, uc001adi.2, uc001adi.3, uc001adi.4, uc001adi.5, uc001adi.6
UCSC ID: ENST00000263741.12
RefSeq Accession: NM_016547
CCDS: CCDS12.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.