Human Gene NOL9 (ENST00000377705.6) from GENCODE V44
Description: Homo sapiens nucleolar protein 9 (NOL9), mRNA. (from RefSeq NM_024654)
Gencode Transcript: ENST00000377705.6
Gencode Gene: ENSG00000162408.11
Transcript (Including UTRs)
Position: hg38 chr1:6,521,347-6,554,513 Size: 33,167 Total Exon Count: 12 Strand: -
Coding Region
Position: hg38 chr1:6,525,854-6,554,502 Size: 28,649 Coding Exon Count: 12
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: NOL9_HUMAN
DESCRIPTION: RecName: Full=Polynucleotide 5'-hydroxyl-kinase NOL9; EC=2.7.1.-; AltName: Full=Nucleolar protein 9;
FUNCTION: Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Colocalizes with pre-60S rRNPs particles.SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.SEQUENCE CAUTION: Sequence=BAB15611.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR010655 - Pre-mRNA_cleavage_cplxII_Clp1
Pfam Domains: PF06807 - Pre-mRNA cleavage complex II protein Clp1
ModBase Predicted Comparative 3D Structure on Q5SY16
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF383933 - JP 2014500723-A/191436: Polycomb-Associated Non-Coding RNAs.MA619510 - JP 2018138019-A/191436: Polycomb-Associated Non-Coding RNAs.AK091284 - Homo sapiens cDNA FLJ33965 fis, clone CTONG2019063.AX746895 - Sequence 420 from Patent EP1308459.AK289653 - Homo sapiens cDNA FLJ75381 complete cds, highly similar to Homo sapiens nucleolar protein 9 (NOL9), mRNA.BC110849 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone MGC:131821 IMAGE:6167575), complete cds.BC105095 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone MGC:132755 IMAGE:8144098), complete cds.BC112278 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone MGC:138483 IMAGE:8327746), complete cds.BC143646 - Homo sapiens cDNA clone IMAGE:9052160.HQ258631 - Synthetic construct Homo sapiens clone IMAGE:100073186 nucleolar protein 9 (NOL9) gene, encodes complete protein.KJ899555 - Synthetic construct Homo sapiens clone ccsbBroadEn_08949 NOL9 gene, encodes complete protein.KJ901072 - Synthetic construct Homo sapiens clone ccsbBroadEn_10466 NOL9 gene, encodes complete protein.AK026976 - Homo sapiens cDNA: FLJ23323 fis, clone HEP12456.BC073860 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone IMAGE:3852937).JD490265 - Sequence 471289 from Patent EP1572962.JD235769 - Sequence 216793 from Patent EP1572962.JD168023 - Sequence 149047 from Patent EP1572962.JD394186 - Sequence 375210 from Patent EP1572962.JD085436 - Sequence 66460 from Patent EP1572962.JD058592 - Sequence 39616 from Patent EP1572962.JD247160 - Sequence 228184 from Patent EP1572962.JD547523 - Sequence 528547 from Patent EP1572962.JD436600 - Sequence 417624 from Patent EP1572962.JD492808 - Sequence 473832 from Patent EP1572962.JD300998 - Sequence 282022 from Patent EP1572962.JD415173 - Sequence 396197 from Patent EP1572962.JD147744 - Sequence 128768 from Patent EP1572962.JD524878 - Sequence 505902 from Patent EP1572962.JD352628 - Sequence 333652 from Patent EP1572962.JD352627 - Sequence 333651 from Patent EP1572962.JD227532 - Sequence 208556 from Patent EP1572962.JD140621 - Sequence 121645 from Patent EP1572962.JD153209 - Sequence 134233 from Patent EP1572962.JD198429 - Sequence 179453 from Patent EP1572962.JD547570 - Sequence 528594 from Patent EP1572962.JD547569 - Sequence 528593 from Patent EP1572962.JD161501 - Sequence 142525 from Patent EP1572962.JD153208 - Sequence 134232 from Patent EP1572962.JD476982 - Sequence 458006 from Patent EP1572962.JD256641 - Sequence 237665 from Patent EP1572962.JD560776 - Sequence 541800 from Patent EP1572962.JD457556 - Sequence 438580 from Patent EP1572962.JD541875 - Sequence 522899 from Patent EP1572962.JD443445 - Sequence 424469 from Patent EP1572962.JD517258 - Sequence 498282 from Patent EP1572962.JD105399 - Sequence 86423 from Patent EP1572962.JD518172 - Sequence 499196 from Patent EP1572962.JD076882 - Sequence 57906 from Patent EP1572962.BC009257 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone IMAGE:3948222), partial cds.LF357505 - JP 2014500723-A/165008: Polycomb-Associated Non-Coding RNAs.MA593082 - JP 2018138019-A/165008: Polycomb-Associated Non-Coding RNAs.BC012439 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone IMAGE:3859950), partial cds.BC063639 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone IMAGE:4452792), partial cds.BC094836 - Homo sapiens nucleolar protein 9, mRNA (cDNA clone IMAGE:5094034), partial cds.JD456058 - Sequence 437082 from Patent EP1572962.LF357504 - JP 2014500723-A/165007: Polycomb-Associated Non-Coding RNAs.MA593081 - JP 2018138019-A/165007: Polycomb-Associated Non-Coding RNAs.LF357502 - JP 2014500723-A/165005: Polycomb-Associated Non-Coding RNAs.MA593079 - JP 2018138019-A/165005: Polycomb-Associated Non-Coding RNAs.LF357498 - JP 2014500723-A/165001: Polycomb-Associated Non-Coding RNAs.MA593075 - JP 2018138019-A/165001: Polycomb-Associated Non-Coding RNAs.LF357496 - JP 2014500723-A/164999: Polycomb-Associated Non-Coding RNAs.MA593073 - JP 2018138019-A/164999: Polycomb-Associated Non-Coding RNAs.LF357495 - JP 2014500723-A/164998: Polycomb-Associated Non-Coding RNAs.MA593072 - JP 2018138019-A/164998: Polycomb-Associated Non-Coding RNAs.LF357494 - JP 2014500723-A/164997: Polycomb-Associated Non-Coding RNAs.MA593071 - JP 2018138019-A/164997: Polycomb-Associated Non-Coding RNAs.JD393620 - Sequence 374644 from Patent EP1572962.LF357489 - JP 2014500723-A/164992: Polycomb-Associated Non-Coding RNAs.MA593066 - JP 2018138019-A/164992: Polycomb-Associated Non-Coding RNAs.LF357487 - JP 2014500723-A/164990: Polycomb-Associated Non-Coding RNAs.MA593064 - JP 2018138019-A/164990: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000377705.1, ENST00000377705.2, ENST00000377705.3, ENST00000377705.4, ENST00000377705.5, NM_024654, NOL9_HUMAN, Q2NL84, Q4VBY3, Q5SY16, Q6P472, Q7L4D6, Q96EE0, Q9H5L4, uc001ans.1, uc001ans.2, uc001ans.3, uc001ans.4, uc001ans.5UCSC ID: ENST00000377705.6RefSeq Accession: NM_024654
Protein: Q5SY16
(aka NOL9_HUMAN)
CCDS: CCDS80.1
Methods, Credits, and Use Restrictions
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