Human Gene FBXO2 (ENST00000354287.5) from GENCODE V44
Description: Homo sapiens F-box protein 2 (FBXO2), mRNA. (from RefSeq NM_012168) RefSeq Summary (NM_012168): This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000354287.5 Gencode Gene: ENSG00000116661.11 Transcript (Including UTRs) Position: hg38 chr1:11,648,387-11,654,429 Size: 6,043 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:11,648,694-11,654,340 Size: 5,647 Coding Exon Count: 6
ID:FBX2_HUMAN DESCRIPTION: RecName: Full=F-box only protein 2; FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Microsome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). SIMILARITY: Contains 1 F-box domain. SIMILARITY: Contains 1 FBA (F-box associated) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UK22
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006464 cellular protein modification process GO:0006508 proteolysis GO:0006511 ubiquitin-dependent protein catabolic process GO:0006516 glycoprotein catabolic process GO:0008285 negative regulation of cell proliferation GO:0016567 protein ubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031396 regulation of protein ubiquitination GO:0043687 post-translational protein modification
US Server
