Human Gene PADI3 (ENST00000375460.3) from GENCODE V44
Description: Homo sapiens peptidyl arginine deiminase 3 (PADI3), mRNA. (from RefSeq NM_016233) RefSeq Summary (NM_016233): This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000375460.3 Gencode Gene: ENSG00000142619.4 Transcript (Including UTRs) Position: hg38 chr1:17,249,098-17,284,233 Size: 35,136 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr1:17,249,138-17,283,079 Size: 33,942 Coding Exon Count: 16
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULW8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.