Human Gene CDA (ENST00000375071.4) from GENCODE V44
Description: Homo sapiens cytidine deaminase (CDA), mRNA. (from RefSeq NM_001785) RefSeq Summary (NM_001785): This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000375071.4 Gencode Gene: ENSG00000158825.6 Transcript (Including UTRs) Position: hg38 chr1:20,589,097-20,618,903 Size: 29,807 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr1:20,589,130-20,618,568 Size: 29,439 Coding Exon Count: 4
ID:CDD_HUMAN DESCRIPTION: RecName: Full=Cytidine deaminase; EC=3.5.4.5; AltName: Full=Cytidine aminohydrolase; FUNCTION: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3). COFACTOR: Zinc. SUBUNIT: Homotetramer. TISSUE SPECIFICITY: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines. SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P32320
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.