Human Gene HNRNPR (ENST00000302271.11) from GENCODE V44
Description: Homo sapiens heterogeneous nuclear ribonucleoprotein R (HNRNPR), transcript variant 2, mRNA. (from RefSeq NM_005826) RefSeq Summary (NM_005826): This gene encodes an RNA-binding protein that is a member of the spliceosome C complex, which functions in pre-mRNA processing and transport. The encoded protein also promotes transcription at the c-fos gene. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000302271.11 Gencode Gene: ENSG00000125944.21 Transcript (Including UTRs) Position: hg38 chr1:23,304,688-23,344,284 Size: 39,597 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr1:23,310,454-23,341,008 Size: 30,555 Coding Exon Count: 10
ID:HNRPR_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein R; Short=hnRNP R; FUNCTION: Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus. SUBUNIT: Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with GTPBP1. INTERACTION: P16333:NCK1; NbExp=2; IntAct=EBI-713419, EBI-389883; SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43390
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BX647784 - Homo sapiens mRNA; cDNA DKFZp686F0586 (from clone DKFZp686F0586). BX640912 - Homo sapiens mRNA; cDNA DKFZp686A13234 (from clone DKFZp686A13234). BC001449 - Homo sapiens heterogeneous nuclear ribonucleoprotein R, mRNA (cDNA clone MGC:2039 IMAGE:3139052), complete cds. LP895168 - Sequence 32 from Patent EP3253886. AF000364 - Homo sapiens heterogeneous nuclear ribonucleoprotein R mRNA, complete cds. BC110389 - Homo sapiens heterogeneous nuclear ribonucleoprotein R, mRNA (cDNA clone IMAGE:5187023), partial cds. AK297382 - Homo sapiens cDNA FLJ53358 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein R. AK300029 - Homo sapiens cDNA FLJ54544 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein R. AK297405 - Homo sapiens cDNA FLJ53360 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein R. DQ351905 - Homo sapiens heterogeneous nuclear ribonucleoprotein-R2 mRNA, complete cds. DQ892168 - Synthetic construct clone IMAGE:100004798; FLH183638.01X; RZPDo839E11142D heterogeneous nuclear ribonucleoprotein R (HNRPR) gene, encodes complete protein. AK313142 - Homo sapiens cDNA, FLJ93632, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein R (HNRPR), mRNA. KJ892971 - Synthetic construct Homo sapiens clone ccsbBroadEn_02365 HNRNPR gene, encodes complete protein. DQ895362 - Synthetic construct Homo sapiens clone IMAGE:100009822; FLH183634.01L; RZPDo839E11141D heterogeneous nuclear ribonucleoprotein R (HNRPR) gene, encodes complete protein. AB385093 - Synthetic construct DNA, clone: pF1KB5396, Homo sapiens HNRNPR gene for heterogeneous nuclear ribonucleoprotein R, complete cds, without stop codon, in Flexi system. AK311519 - Homo sapiens cDNA, FLJ18561. CU674710 - Synthetic construct Homo sapiens gateway clone IMAGE:100017747 5' read HNRPR mRNA. LF206674 - JP 2014500723-A/14177: Polycomb-Associated Non-Coding RNAs. MA442251 - JP 2018138019-A/14177: Polycomb-Associated Non-Coding RNAs. AK001846 - Homo sapiens cDNA FLJ10984 fis, clone PLACE1001810. LF357046 - JP 2014500723-A/164549: Polycomb-Associated Non-Coding RNAs. MA592623 - JP 2018138019-A/164549: Polycomb-Associated Non-Coding RNAs. AK098580 - Homo sapiens cDNA FLJ25714 fis, clone TST05093, highly similar to Homo sapiens heterogeneous nuclear ribonucleoprotein R mRNA. BX538163 - Homo sapiens mRNA; cDNA DKFZp686O0665 (from clone DKFZp686O0665); complete cds. JD551120 - Sequence 532144 from Patent EP1572962. JD288705 - Sequence 269729 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O43390 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing
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