Human Gene TRNP1 (ENST00000522111.3) from GENCODE V44
  Description: Homo sapiens TMF1 regulated nuclear protein 1 (TRNP1), mRNA. (from RefSeq NM_001013642)
Gencode Transcript: ENST00000522111.3
Gencode Gene: ENSG00000253368.4
Transcript (Including UTRs)
   Position: hg38 chr1:26,993,692-27,000,886 Size: 7,195 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr1:26,993,787-26,994,470 Size: 684 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:26,993,692-27,000,886)mRNA (may differ from genome)Protein (227 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRNP1_HUMAN
DESCRIPTION: RecName: Full=TMF-regulated nuclear protein 1;
FUNCTION: When overexpressed, accelerates the proliferation rate of cells by enhancing their progression through key cell-cycle transition points (By similarity).
SUBUNIT: Interacts with TMF1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
PTM: Ubiquitinated, leading to its degradation by the proteasome (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 63.49 RPKM in Cells - Cultured fibroblasts
Total median expression: 611.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.0095-0.400 Picture PostScript Text
3' UTR -378.901182-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q6NT89
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0021696 cerebellar cortex morphogenesis
GO:0042127 regulation of cell proliferation
GO:0051726 regulation of cell cycle
GO:0061351 neural precursor cell proliferation

Cellular Component:
GO:0005634 nucleus
GO:0005719 nuclear euchromatin


-  Descriptions from all associated GenBank mRNAs
  BC069216 - Homo sapiens TMF1-regulated nuclear protein 1, mRNA (cDNA clone MGC:78739 IMAGE:6376829), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: C1orf225, ENST00000522111.1, ENST00000522111.2, NM_001013642, Q6NT89, TRNP, TRNP1_HUMAN, uc001bnj.1, uc001bnj.2, uc001bnj.3, uc001bnj.4, uc001bnj.5, uc001bnj.6
UCSC ID: ENST00000522111.3
RefSeq Accession: NM_001013642
Protein: Q6NT89 (aka TRNP1_HUMAN)
CCDS: CCDS41289.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.