Human Gene PHACTR4 (ENST00000373839.8) from GENCODE V44
Description: Homo sapiens phosphatase and actin regulator 4 (PHACTR4), transcript variant 6, mRNA. (from RefSeq NM_001350161) RefSeq Summary (NM_001048183): This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000373839.8 Gencode Gene: ENSG00000204138.13 Transcript (Including UTRs) Position: hg38 chr1:28,369,740-28,500,364 Size: 130,625 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr1:28,407,448-28,496,549 Size: 89,102 Coding Exon Count: 13
ID:PHAR4_HUMAN DESCRIPTION: RecName: Full=Phosphatase and actin regulator 4; FUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). SUBUNIT: Binds PPP1CA and actin (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the phosphatase and actin regulator family. SIMILARITY: Contains 3 RPEL repeats. SEQUENCE CAUTION: Sequence=AAG35507.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH68508.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAB14483.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15130.1; Type=Frameshift; Positions=51; Sequence=CAH18286.1; Type=Frameshift; Positions=53;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IZ21
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
