Human Gene NASP (ENST00000350030.8) from GENCODE V44
Description: Homo sapiens nuclear autoantigenic sperm protein (NASP), transcript variant 2, mRNA. (from RefSeq NM_002482) RefSeq Summary (NM_002482): This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000350030.8 Gencode Gene: ENSG00000132780.17 Transcript (Including UTRs) Position: hg38 chr1:45,584,041-45,618,893 Size: 34,853 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr1:45,584,147-45,618,141 Size: 33,995 Coding Exon Count: 15
ID:NASP_HUMAN DESCRIPTION: RecName: Full=Nuclear autoantigenic sperm protein; Short=NASP; FUNCTION: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity). SUBUNIT: Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. TISSUE SPECIFICITY: Isoform 1 is testis- and sperm-specific. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the NASP family. SIMILARITY: Contains 3 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49321
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.