Human Gene HS2ST1 (ENST00000370551.8) from GENCODE V44
Description: Homo sapiens heparan sulfate 2-O-sulfotransferase 1 (HS2ST1), transcript variant 2, mRNA. (from RefSeq NM_001134492) RefSeq Summary (NM_001134492): Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]. Gencode Transcript: ENST00000370551.8 Gencode Gene: ENSG00000153936.18 Transcript (Including UTRs) Position: hg38 chr1:86,914,648-87,098,445 Size: 183,798 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr1:86,915,037-87,097,939 Size: 182,903 Coding Exon Count: 5
ID:HS2ST_HUMAN DESCRIPTION: RecName: Full=Heparan sulfate 2-O-sulfotransferase 1; Short=2-O-sulfotransferase; Short=2OST; EC=2.8.2.-; FUNCTION: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). SUBUNIT: Interacts with the C5-epimerase GLCE (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). PTM: N-glycosylated (By similarity). SIMILARITY: Belongs to the sulfotransferase 3 family. SEQUENCE CAUTION: Sequence=BAA32293.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7LGA3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.