Human Gene RBMXL1 (ENST00000321792.5) Description and Page Index
  Description: Homo sapiens RBMX like 1 (RBMXL1), transcript variant 2, mRNA. (from RefSeq NM_019610)
RefSeq Summary (NM_019610): This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. [provided by RefSeq, Jun 2009].
Gencode Transcript: ENST00000321792.5
Gencode Gene: ENSG00000213516.10
Transcript (Including UTRs)
   Position: hg38 chr1:88,979,456-88,992,772 Size: 13,317 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:88,982,654-88,983,826 Size: 1,173 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:88,979,456-88,992,772)mRNA (may differ from genome)Protein (390 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCHPRD
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RMXL1_HUMAN
DESCRIPTION: RecName: Full=RNA binding motif protein, X-linked-like-1; AltName: Full=Heterogeneous nuclear ribonucleoprotein G-like 1; Contains: RecName: Full=RNA binding motif protein, X-linked-like-1, N-terminally processed;
FUNCTION: RNA-binding protein which may be involved in pre-mRNA splicing (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
MISCELLANEOUS: According to some authors, RBMXL1 is a RBMX retrogene on chromosome X which is likely to be functional (PubMed:16201836).
SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
CAUTION: The first non-coding exon of RBMXL1 is in common with that of CCBL2.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.09 RPKM in Fallopian Tube
Total median expression: 230.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -143.10428-0.334 Picture PostScript Text
3' UTR -808.393198-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR012604 - RBM1CTR
IPR000504 - RRM_dom

Pfam Domains:
PF08081 - RBM1CTR (NUC064) family
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

ModBase Predicted Comparative 3D Structure on Q96E39
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Biological Process:
GO:0006397 mRNA processing
GO:0008380 RNA splicing

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AY028624 - Homo sapiens kynurenine aminotransferase III mRNA, complete cds.
AK057176 - Homo sapiens cDNA FLJ32614 fis, clone STOMA2000121, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 2, mRNA.
AL833593 - Homo sapiens mRNA; cDNA DKFZp686J0664 (from clone DKFZp686J0664).
AK301326 - Homo sapiens cDNA FLJ56161 complete cds, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 1, mRNA.
AK315917 - Homo sapiens cDNA, FLJ78816 complete cds, highly similar to Homo sapiens kynurenine aminotransferase III (KAT3), transcript variant 1, mRNA.
CR627392 - Homo sapiens mRNA; cDNA DKFZp686D19113 (from clone DKFZp686D19113).
AL832785 - Homo sapiens mRNA; cDNA DKFZp667D0223 (from clone DKFZp667D0223).
AL832554 - Homo sapiens mRNA; cDNA DKFZp547N1117 (from clone DKFZp547N1117).
BC012942 - Homo sapiens cysteine conjugate-beta lyase 2, mRNA (cDNA clone MGC:9398 IMAGE:3875565), complete cds.
JD154864 - Sequence 135888 from Patent EP1572962.
JD309421 - Sequence 290445 from Patent EP1572962.
JD294794 - Sequence 275818 from Patent EP1572962.
JD345117 - Sequence 326141 from Patent EP1572962.
JD314485 - Sequence 295509 from Patent EP1572962.
JD216316 - Sequence 197340 from Patent EP1572962.
JD081714 - Sequence 62738 from Patent EP1572962.
JD501313 - Sequence 482337 from Patent EP1572962.
JD162613 - Sequence 143637 from Patent EP1572962.
JD429927 - Sequence 410951 from Patent EP1572962.
JD229598 - Sequence 210622 from Patent EP1572962.
JD093559 - Sequence 74583 from Patent EP1572962.
JD284842 - Sequence 265866 from Patent EP1572962.
JD120317 - Sequence 101341 from Patent EP1572962.
JD456366 - Sequence 437390 from Patent EP1572962.
JD466068 - Sequence 447092 from Patent EP1572962.
JD379035 - Sequence 360059 from Patent EP1572962.
JD273966 - Sequence 254990 from Patent EP1572962.
JD549936 - Sequence 530960 from Patent EP1572962.
JD184357 - Sequence 165381 from Patent EP1572962.
JD450611 - Sequence 431635 from Patent EP1572962.
JD074451 - Sequence 55475 from Patent EP1572962.
JD309456 - Sequence 290480 from Patent EP1572962.
JD473233 - Sequence 454257 from Patent EP1572962.
JD566606 - Sequence 547630 from Patent EP1572962.
LF208250 - JP 2014500723-A/15753: Polycomb-Associated Non-Coding RNAs.
MA443827 - JP 2018138019-A/15753: Polycomb-Associated Non-Coding RNAs.
LF210019 - JP 2014500723-A/17522: Polycomb-Associated Non-Coding RNAs.
MA445596 - JP 2018138019-A/17522: Polycomb-Associated Non-Coding RNAs.
JD346822 - Sequence 327846 from Patent EP1572962.
JD312276 - Sequence 293300 from Patent EP1572962.
JD181067 - Sequence 162091 from Patent EP1572962.
JD068158 - Sequence 49182 from Patent EP1572962.
AB462999 - Synthetic construct DNA, clone: pF1KB5348, Homo sapiens CCBL2 gene for cysteine conjugate-beta lyase 2, without stop codon, in Flexi system.
LF334086 - JP 2014500723-A/141589: Polycomb-Associated Non-Coding RNAs.
MA569663 - JP 2018138019-A/141589: Polycomb-Associated Non-Coding RNAs.
LF334085 - JP 2014500723-A/141588: Polycomb-Associated Non-Coding RNAs.
MA569662 - JP 2018138019-A/141588: Polycomb-Associated Non-Coding RNAs.
LF373914 - JP 2014500723-A/181417: Polycomb-Associated Non-Coding RNAs.
MA609491 - JP 2018138019-A/181417: Polycomb-Associated Non-Coding RNAs.
LF334083 - JP 2014500723-A/141586: Polycomb-Associated Non-Coding RNAs.
MA569660 - JP 2018138019-A/141586: Polycomb-Associated Non-Coding RNAs.
LF373915 - JP 2014500723-A/181418: Polycomb-Associated Non-Coding RNAs.
MA609492 - JP 2018138019-A/181418: Polycomb-Associated Non-Coding RNAs.
LF373916 - JP 2014500723-A/181419: Polycomb-Associated Non-Coding RNAs.
MA609493 - JP 2018138019-A/181419: Polycomb-Associated Non-Coding RNAs.
LF334082 - JP 2014500723-A/141585: Polycomb-Associated Non-Coding RNAs.
MA569659 - JP 2018138019-A/141585: Polycomb-Associated Non-Coding RNAs.
LF373917 - JP 2014500723-A/181420: Polycomb-Associated Non-Coding RNAs.
MA609494 - JP 2018138019-A/181420: Polycomb-Associated Non-Coding RNAs.
LF334081 - JP 2014500723-A/141584: Polycomb-Associated Non-Coding RNAs.
MA569658 - JP 2018138019-A/141584: Polycomb-Associated Non-Coding RNAs.
JD041166 - Sequence 22190 from Patent EP1572962.
JD317503 - Sequence 298527 from Patent EP1572962.
JD201024 - Sequence 182048 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_019610, Q96E39, RMXL1_HUMAN, uc001dms.1, uc001dms.2, uc001dms.3, uc001dms.4
UCSC ID: uc001dms.4
RefSeq Accession: NM_019610
Protein: Q96E39 (aka RMXL1_HUMAN)
CCDS: CCDS716.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.